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MECHANISMS OF AGEING AND DEVELOPMENT (2010)
Chronic ingestion of 2-deoxy-D-glucose induces cardiac vacuolization and increases mortality in rats
Robin K. Minor et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2010)
Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy
E. Morselli et al.
CELL DEATH & DISEASE (2010)
miR-30 Regulates Mitochondrial Fission through Targeting p53 and the Dynamin-Related Protein-1 Pathway
Jincheng Li et al.
PLOS GENETICS (2010)
A Mutation in the Mitochondrial Fission Gene Dnm1l Leads to Cardiomyopathy
Houman Ashrafian et al.
PLOS GENETICS (2010)
LKB1 and AMP-activated protein kinase control of mTOR signalling and growth
R. J. Shaw
ACTA PHYSIOLOGICA (2009)
Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C-elegans
Eric L. Greer et al.
AGING CELL (2009)
Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle
Orsolya M. Palacios et al.
AGING-US (2009)
mTOR's role in ageing: protein synthesis or autophagy?
Sarah L. Hands et al.
AGING-US (2009)
Suppression of 5′-AMP-activated protein kinase activity does not impair recovery of contractile function during reperfusion of ischemic hearts
Clifford D. L. Folmes et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2009)
Transient opening of mitochondrial permeability transition pore by reactive oxygen species protects myocardium from ischemia-reperfusion injury
Masao Saotome et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2009)
5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside Increases Myocardial Glucose Uptake during Reperfusion and Induces Late Pre-conditioning: Potential Role of AMP-Activated Protein Kinase
Steen B. Kristiansen et al.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2009)
Presence of connexin 43 in subsarcolemmal, but not in interfibrillar cardiomyocyte mitochondria
Kerstin Boengler et al.
BASIC RESEARCH IN CARDIOLOGY (2009)
Cardioprotection requires taking out the trash
Roberta A. Gottlieb et al.
BASIC RESEARCH IN CARDIOLOGY (2009)
Mitochondrial pathways for ROS formation and myocardial injury: the relevance of p66(Shc) and monoamine oxidase
Fabio Di Lisa et al.
BASIC RESEARCH IN CARDIOLOGY (2009)
Resveratrol protects cardiomyocytes from hypoxia-induced apoptosis through the SIRT1-FoxO1 pathway
Chun-Juan Chen et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
CTRP8 and CTRP9B are novel proteins that hetero-oligomerize with C1q/TNF family members
Jonathan M. Peterson et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
How mitochondria produce reactive oxygen species
Michael P. Murphy
BIOCHEMICAL JOURNAL (2009)
The cardioprotective effects elicited by p66Shc ablation demonstrate the crucial role of mitochondrial ROS formation in ischemia/reperfusion injury
Andrea Carpi et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2009)
The TOR pathway comes of age
Monique N. Stanfel et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2009)
Caloric restriction-induced life extension of rats and mice: A critique of proposed mechanisms
Edward J. Masoro
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2009)
A comparative study of myocardial function and morphology during fasting/refeeding and food restriction in rats
Matheus Fécchio Pinotti et al.
CARDIOVASCULAR PATHOLOGY (2009)
Loss of cardioprotection with ageing
Kerstin Boengler et al.
CARDIOVASCULAR RESEARCH (2009)
Mitochondrial OPA1, apoptosis, and heart failure
Le Chen et al.
CARDIOVASCULAR RESEARCH (2009)
SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle
Takashi Nakagawa et al.
CELL (2009)
Resveratrol is Not a Direct Activator of SIRT1 Enzyme Activity
Dirk Beher et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2009)
AMP-Activated Protein Kinase Deficiency Enhances Myocardial Ischemia/Reperfusion Injury but Has Minimal Effect on the Antioxidant/Antinitrative Protection of Adiponectin
Yajing Wang et al.
CIRCULATION (2009)
Metformin Prevents Progression of Heart Failure in Dogs Role of AMP-Activated Protein Kinase
Hideyuki Sasaki et al.
CIRCULATION (2009)
Suppression of Phosphoinositide 3-Kinase Prevents Cardiac Aging in Mice
Yasutaka Inuzuka et al.
CIRCULATION (2009)
Nicotinamide Phosphoribosyltransferase Regulates Cell Survival Through NAD+ Synthesis in Cardiac Myocytes
Chiao-Po Hsu et al.
CIRCULATION RESEARCH (2009)
Activation of AMP-Activated Protein Kinase by Metformin Improves Left Ventricular Function and Survival in Heart Failure
Susheel Gundewar et al.
CIRCULATION RESEARCH (2009)
Human longevity and 11p15.5: a study in 1321 centenarians
Francesco Lescai et al.
EUROPEAN JOURNAL OF HUMAN GENETICS (2009)
Identification and characterization of CTRP9, a novel secreted glycoprotein, from adipose tissue that reduces serum glucose in mice and forms heterotrimers with adiponectin
G. William Wong et al.
FASEB JOURNAL (2009)
Caloric Restriction Stimulates Revascularization in Response to Ischemia via Adiponectin-mediated Activation of Endothelial Nitric-oxide Synthase
Megumi Kondo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
FoxO Transcription Factors Promote Autophagy in Cardiomyocytes
Arunima Sengupta et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Prolonged Exposure to Insulin Suppresses Mitochondrial Production in Primary Hepatocytes
Hui-Yu Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Metformin Prevents Myocardial Reperfusion Injury by Activating the Adenosine Receptor
Marta Paiva et al.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2009)
Cardioprotection by adaptation to ischaemia augments autophagy in association with BAG-1 protein
Narasimman Gurusamy et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2009)
Beneficial Effects of Mammalian Target of Rapamycin Inhibition on Left Ventricular Remodeling After Myocardial Infarction
Sebastian J. Buss et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2009)
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
Carles Canto et al.
NATURE (2009)
C. elegans longevity pathways converge to decrease mitochondrial membrane potential
Bernard D. Lemire et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2009)
Bioenergetics and permeability transition pore opening in heart subsarcolemmal and interfibrillar mitochondria: Effects of aging and lifelong calorie restriction
Tim Hofer et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2009)
Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
Ricki J. Colman et al.
SCIENCE (2009)
Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span
Colin Selman et al.
SCIENCE (2009)
Nampt: linking NAD biology, metabolism and cancer
Antje Garten et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2009)
Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity
Camille C. Caldeira da Silva et al.
AGING CELL (2008)
Effect of sirolimus on left ventricular hypertrophy in kidney transplant recipients: A 1-year nonrandomized controlled trial
Ernesto Paoletti et al.
AMERICAN JOURNAL OF KIDNEY DISEASES (2008)
Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat heart mitochondria
Qun Chen et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2008)
Impact of 6-mo caloric restriction on myocardial ischemic tolerance: possible involvement of nitric oxide-dependent increase in nuclear Sirt1
Ken Shinmura et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2008)
Bnip3 functions as a mitochondrial sensor of oxidative stress during myocardial ischemia and reperfusion
Dieter A. Kubli et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2008)
Myocardial ischemic postconditioning against ischemia-reperfusion is impaired in ob/ob mice
Omar Bouhidel et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2008)
Metformin induces cardioprotection against ischaemia/reperfusion injury in the rat heart 24 hours after administration
Lasse Solskov et al.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2008)
Molecular, biochemical and functional characterizations of C1q/TNF family members: adipose-tissue-selective expression patterns, regulation by PPAR-gamma agonist, cysteine-mediated oligomerizations, combinatorial associations and metabolic functions
G. William Wong et al.
BIOCHEMICAL JOURNAL (2008)
Adiponectin protects against myocardial ischaemia-reperfusion injury via AMP-activated protein kinase, Akt, and nitric oxide
Adrian T. Gonon et al.
CARDIOVASCULAR RESEARCH (2008)
Autophagy in the pathogenesis of disease
Beth Levine et al.
CELL (2008)
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span
Kevin J. Pearson et al.
CELL METABOLISM (2008)
Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-induced Metabolic Disorders by Enhancing Fat Oxidation
Jerome N. Feige et al.
CELL METABOLISM (2008)
Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice
Olesya Vakhrusheva et al.
CIRCULATION RESEARCH (2008)
Cardioprotection by ischemic postconditioning is lost in aged and STAT3-deficient mice
Kerstin Boengler et al.
CIRCULATION RESEARCH (2008)
Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt
Marcella Fulco et al.
DEVELOPMENTAL CELL (2008)
Sirolimus affects cardiomyocytes to reduce left ventricular mass in heart transplant recipients
Sudhir S. Kushwaha et al.
EUROPEAN HEART JOURNAL (2008)
Mitochondrial biogenesis and healthy aging
Guillermo Lopez-Lluch et al.
EXPERIMENTAL GERONTOLOGY (2008)
Age-specific effects of short- and long-term caloric restriction on the expression of adiponectin and adiponectin receptors: Influence of intensity of food restriction
Bernd Niemann et al.
EXPERIMENTAL GERONTOLOGY (2008)
AMP Activated Protein Kinase-α2 Deficiency Exacerbates Pressure-Overload-Induced Left Ventricular Hypertrophy and Dysfunction in Mice
Ping Zhang et al.
HYPERTENSION (2008)
Cardiac restricted overexpression of kinase-dead mammalian target of rapamycin (mTOR) mutant impairs the mTOR-mediated signaling and cardiac function
Wei-Hua Shen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt
Anita Y. M. Chan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Substrates and regulation mechanisms for the human mitochondrial Sirtuins Sirt3 and Sirt5
Christine Schlicker et al.
JOURNAL OF MOLECULAR BIOLOGY (2008)
SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70
Nagalingam R. Sundaresan et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Mitofusin 2 tethers endoplasmic reticulum to mitochondria
Olga Martins de Brito et al.
NATURE (2008)
SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice
Gino Boily et al.
PLOS ONE (2008)
A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice
Jamie L. Barger et al.
PLOS ONE (2008)
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
In Hye Lee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
Bong-Hyun Ahn et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Metformin protects the ischemic heart by the Akt-mediated inhibition of mitochondrial permeability transition pore opening
Gurpreet S. Bhamra et al.
BASIC RESEARCH IN CARDIOLOGY (2008)
Acute metformin therapy confers cardioprotection against myocardial infarction via AMPK-eNOS-mediated signaling
John W. Calvert et al.
DIABETES (2008)
Cardioprotective effects of short-term caloric restriction are mediated by adiponectin via activation of AMP-activated protein kinase
Ken Shinmura et al.
CIRCULATION (2007)
Conversion to sirolimus as primary immunosuppression attenuates the progression of allograft vasculopathy after cardiac transplantation
Eugenia Raichlin et al.
CIRCULATION (2007)
Mammalian sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation
David B. Lombard et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning
Peter Ferdinandy et al.
PHARMACOLOGICAL REVIEWS (2007)
SIRT1 transgenic mice show phenotypes resembling calorie restriction
Laura Bordone et al.
AGING CELL (2007)
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
Jill C. Milne et al.
NATURE (2007)
Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase
Nidhi Ahuja et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Mitochondrial respiration and membrane potential after low-flow ischemia are not affected by ischemic preconditioning
Kerstin Boengler et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2007)
Age-associated loss in adiponectin-activation by caloric restriction: Lack of compensation by enhanced inducibility of adiponectin paralogs CTRP2 and CTRP7
Susanne Rohrbach et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2007)
The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor
Eric L. Greer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C-elegans
Eric L. Greer et al.
CURRENT BIOLOGY (2007)
Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans
Timothy M. Bass et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2007)
Transcriptional response to aging and caloric restriction in heart and adipose tissue
Nancy J. Linford et al.
AGING CELL (2007)
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival
Hongying Yang et al.
CELL (2007)
SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase
Ilwola Mattagajasingh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Autophagy in the heart and liver during normal aging and calorie restriction
Stephanie E. Wohlgemuth et al.
REJUVENATION RESEARCH (2007)
Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence
Seungmin Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Adipogenic signaling in rat white adipose tissue: Modulation by aging and calorie restriction
Min Zhu et al.
EXPERIMENTAL GERONTOLOGY (2007)
SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction
Fei Wang et al.
AGING CELL (2007)
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
Sibylle Jaeger et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Rapamycin prevents thyroid hormone-induced cardiac hypertrophy
James A. Kuzman et al.
ENDOCRINOLOGY (2007)
Calorie restriction or exercise: effects on coronary heart disease risk factors. A randomized, controlled trial
Luigi Fontana et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2007)
Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1α transcription coactivator
Xinghai Li et al.
NATURE (2007)
Dual cardiac contractile effects of the α2-AMPK deletion in low-flow ischemia and reperfusion
Karla Carvajal et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2007)
Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent
David J. Boocock et al.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2007)
Sirt1 regulates aging and resistance to oxidative stress in the heart
Ralph R. Alcendor et al.
CIRCULATION RESEARCH (2007)
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1α
Zachary Gerhart-Hines et al.
EMBO JOURNAL (2007)
Adiponectin cardioprotection after myocardial ischemia/reperfusion involves the reduction of oxidative/nitrative stress
Ling Tao et al.
CIRCULATION (2007)
Calorie restriction increases muscle mitochondrial biogenesis in healthy humans
Anthony E. Civitarese et al.
PLOS MEDICINE (2007)
Design and synthesis of compounds that extend yeast replicative lifespan
Hongying Yang et al.
AGING CELL (2007)
Long-term activation of adenosine monophosphate-activated protein kinase attenuates pressure-overload-induced cardiac hypertrophy
Hong-Liang Li et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2007)
Excitation-contraction coupling and mitochondrial energetics
Christoph Maack et al.
BASIC RESEARCH IN CARDIOLOGY (2007)
The red wine antioxidant resveratrol prevents cardiomyocyte injury following ischemia-reperfusion via multiple sites and mechanisms
Siew Simg C. Goh et al.
ANTIOXIDANTS & REDOX SIGNALING (2007)
Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy
A. Hamacher-Brady et al.
CELL DEATH AND DIFFERENTIATION (2007)
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α
Marie Lagouge et al.
CELL (2006)
Peroxisome proliferator-activated receptor γ coactivator 1 coactivators, energy hemeostasis, and metabolism
Christoph Handschin et al.
ENDOCRINE REVIEWS (2006)
Resveratrol improves health and survival of mice on a high-calorie diet
Joseph A. Baur et al.
NATURE (2006)
Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes
Anne Hamacher-Brady et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Autophagy as a protective response to Bnip3-mediated apoptotic signaling in the heart
Anne Hamacher-Brady et al.
AUTOPHAGY (2006)
Cardioprotective effect of resveratrol via HO-1 expression involves p38 map kinase and PI-3-kinase signaling, but does not involve NFκB
Samarjit Das et al.
FREE RADICAL RESEARCH (2006)
Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1α transcription and mitochondrial biogenesis in muscle cells
Zhidan Wu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
SIRT4 inhibits glutamate dehydrogehase and opposes the effects of calorie restriction in pancreatic β cells
Marcia C. Haigis et al.
CELL (2006)
Differential changes in respiratory capacity and ischemia tolerance of isolated mitochondria from atrophied and hypertrophied hearts
Heiko Bugger et al.
METABOLISM-CLINICAL AND EXPERIMENTAL (2006)
Cardioprotective effect of resvaratrol pretreatment on myocardial ischemia-reperfusion induced injury in rats
Min Shen et al.
VASCULAR PHARMACOLOGY (2006)
Rapamycin confers preconditioning-like protection against ischemia-reperfusion injury in isolated mouse heart and cardiomyocytes
Shakil A. Khan et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2006)
Nitric oxide and mitochondrial biogenesis
Enzo Nisoli et al.
JOURNAL OF CELL SCIENCE (2006)
Transcriptional profiling of aging in human muscle reveals a common aging signature
Jacob M. Zahn et al.
PLOS GENETICS (2006)
Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-γ coactivator 1α
Zoltan Arany et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins
Alberto Sanz et al.
FASEB JOURNAL (2006)
Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals - A randomized controlled trial
LK Heilbronn et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2006)
Calorie restriction mimetics: an emerging research field
DK Ingram et al.
AGING CELL (2006)
Depletion of cardiolipin and cytochrome c during ischemia increases hydrogen peroxide production from the electron transport chain
Q Chen et al.
FREE RADICAL BIOLOGY AND MEDICINE (2006)
Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency
G López-Lluch et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase
BJ Davis et al.
DIABETES (2006)
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
R Mostoslavsky et al.
CELL (2006)
Long-term caloric restriction ameliorates the decline in diastolic function in humans
TE Meyer et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2006)
Caloric restriction in humans: Potential pitfalls and health concerns
AJ Dirks et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2006)
Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2α deacetylase activity
JB Pillai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Increase in activity during calorie restriction requires Sirt1
D Chen et al.
SCIENCE (2005)
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
RJ Shaw et al.
SCIENCE (2005)
Oxidative stress by monoamine oxidase mediates receptor-independent cardiomyocyte apoptosis by serotonin and postischemic myocardial injury
P Bianchi et al.
CIRCULATION (2005)
A role for SIR-2.1 regulation of ER stress response genes in determining C-elegans life span
M Viswanathan et al.
DEVELOPMENTAL CELL (2005)
Resveratrol enhances neovascularization in the infarcted rat myocardium through the induction of thioredoxin-1, heme oxygenase-1 and vascular endothelial growth factor
S Kaga et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2005)
Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS
E Nisoli et al.
SCIENCE (2005)
Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2 dependent mechanisms
R Shibata et al.
NATURE MEDICINE (2005)
Adiponectin is synthesized and secreted by human and murine cardiomyocytes
R Piñeiro et al.
FEBS LETTERS (2005)
Uncoupler of oxidative phosphorylation prolongs the lifespan of Drosophila
VI Padalko
BIOCHEMISTRY-MOSCOW (2005)
Short-term caloric restriction improves ischemic tolerance independent of opening of ATP-sensitive K+ channels in both young and aged hearts
K Shinmura et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2005)
Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis
M Giorgio et al.
CELL (2005)
A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle
LM Sparks et al.
DIABETES (2005)
Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury
VJ Adlam et al.
FASEB JOURNAL (2005)
Metformin decreases intracellular production of reactive oxygen species in aortic endothelial cells
N Ouslimani et al.
METABOLISM-CLINICAL AND EXPERIMENTAL (2005)
Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance
RA Miller et al.
AGING CELL (2005)
Mechanism of human SIRT1 activation by resveratrol
MT Borra et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Substrate-specific activation of sirtuins by resveratrol
M Kaeberlein et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes
T Shi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
PGC-1α deficiency causes multi-system energy metabolic derangements:: Muscle dysfunction, abnormal weight control and hepatic steatosis
TC Leone et al.
PLOS BIOLOGY (2005)
Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle
Z Arany et al.
CELL METABOLISM (2005)
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
JT Rodgers et al.
NATURE (2005)
Mitochondria, oxidants, and aging
RS Balaban et al.
CELL (2005)
A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages
D Bellizzi et al.
GENOMICS (2005)
Ischemic preconditioning protects by activating prosurvival kinases at reperfusion
DJ Hausenloy et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2005)
Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators
N Gleyzer et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Tandem action of exercise training and food restriction completely preserves ischemic preconditioning in the aging heart
P Abete et al.
EXPERIMENTAL GERONTOLOGY (2005)
Toward a unified theory of caloric restriction and longevity regulation
DA Sinclair
MECHANISMS OF AGEING AND DEVELOPMENT (2005)
The estrogen-related receptor α (ERRα) functions in PPARγ coactivator 1α (PGC-1α)-induced mitochondrial biogenesis
SN Schreiber et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection
D Hausenloy et al.
CIRCULATION (2004)
Ischemic preconditioning activates AMPK in a PKC-dependent manner and induces GLUT4 up-regulation in the late phase of cardioprotection
Y Nishino et al.
CARDIOVASCULAR RESEARCH (2004)
Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1α:: modulation by p38 MAPK
M Fan et al.
GENES & DEVELOPMENT (2004)
Decrease in mitochondrial complex I activity in ischemic/reperfused rat heart - Involvement of reactive oxygen species and cardiolipin
G Paradies et al.
CIRCULATION RESEARCH (2004)
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
SH Um et al.
NATURE (2004)
Dietary supplementation with 2-deoxy-D-glucose improves cardiovascular and neuroendocrine stress adaptation in rats
RQ Wan et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2004)
An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster
JH Bauer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
JG Wood et al.
NATURE (2004)
The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span
K Jia et al.
DEVELOPMENT (2004)
The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C-elegans
J Apfeld et al.
GENES & DEVELOPMENT (2004)
Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte
AYM Chan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells
JR Revollo et al.
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A novel assay for replicative lifespan in Saccharomyces cerevisiae
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FEMS YEAST RESEARCH (2004)
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DG Hardie
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Metabolic adaptations to fasting and chronic caloric restriction in heart, muscle, and liver do not include changes in AMPK activity
AA Gonzalez et al.
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Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
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FREE RADICAL BIOLOGY AND MEDICINE (2003)
Rapamycin attenuates load-induced cardiac hypertrophy in mice
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G Barja
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Akt/Protein kinase B promotes organ growth in transgenic mice
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AMERICAN JOURNAL OF HYPERTENSION (2002)
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HORMONE AND METABOLIC RESEARCH (2002)
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BRITISH JOURNAL OF PHARMACOLOGY (2002)
High levels of fatty acids delay the recovery of intracellular pH and cardiac efficiency in post-ischemic hearts by inhibiting glucose oxidation
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