相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease
Stephen Salloway et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
Informed Consent, Big Data, and the Oxymoron of Research That Is Not Research
John P. A. Ioannidis
AMERICAN JOURNAL OF BIOETHICS (2013)
Pharmacokinetics, Pharmacodynamics and Physiologically-Based Pharmacokinetic Modelling of Monoclonal Antibodies
Miroslav Dostalek et al.
CLINICAL PHARMACOKINETICS (2013)
Intracellular Drug Concentrations
C. T. Dollery
CLINICAL PHARMACOLOGY & THERAPEUTICS (2013)
Metabolite Profiles During Oral Glucose Challenge
Jennifer E. Ho et al.
DIABETES (2013)
On the Immortality of Television Sets: Function in the Human Genome According to the Evolution-Free Gospel of ENCODE
Dan Graur et al.
GENOME BIOLOGY AND EVOLUTION (2013)
Overview of Positron Emission Tomography, Hybrid Positron Emission Tomography Instrumentation, and Positron Emission Tomography Quantification
Thomas C. Kwee et al.
JOURNAL OF THORACIC IMAGING (2013)
Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs
Christine Katlama et al.
LANCET (2013)
THE BIG CHALLENGES OF BIG DATA
Vivien Marx
NATURE (2013)
Criteria for the use of omics-based predictors in clinical trials
Lisa M. McShane et al.
NATURE (2013)
A statin-dependent QTL for GATM expression is associated with statin-induced myopathy
Lara M. Mangravite et al.
NATURE (2013)
Complete viral RNA genome sequencing of ultra-low copy samples by sequence-independent amplification
Christine M. Malboeuf et al.
NUCLEIC ACIDS RESEARCH (2013)
Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay
Daniel Martinez Molina et al.
SCIENCE (2013)
Positron emission tomography molecular imaging for drug development
Paul M. Matthews et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2012)
Current advances in humanized mouse models
Ryoji Ito et al.
CELLULAR & MOLECULAR IMMUNOLOGY (2012)
Lapatinib-Induced Liver Injury Characterized by Class II HLA and Gilbert's Syndrome Genotypes
C. F. Spraggs et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2012)
Monoclonal antibody therapeutics: history and future
Nicholas A. P. S. Buss et al.
CURRENT OPINION IN PHARMACOLOGY (2012)
Computational Insights for the Discovery of Non-ATP Competitive Inhibitors of MAP Kinases
Michael J. Schnieders et al.
CURRENT PHARMACEUTICAL DESIGN (2012)
Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival
Paul Morgan et al.
DRUG DISCOVERY TODAY (2012)
MicroRNAs in Liver Disease
Xin Wei Wang et al.
GASTROENTEROLOGY (2012)
Universal Amplification, Next-Generation Sequencing, and Assembly of HIV-1 Genomes
Astrid Gall et al.
JOURNAL OF CLINICAL MICROBIOLOGY (2012)
Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia
Wu Yin et al.
JOURNAL OF LIPID RESEARCH (2012)
Single-domain antibodies: a versatile and rich source of binders for breast cancer diagnostic approaches
Klervi Even-Desrumeaux et al.
MOLECULAR BIOSYSTEMS (2012)
FORUM: Genomics ENCODE explained
Joseph R. Ecker
NATURE (2012)
Metabolomics: the apogee of the omics trilogy
Gary J. Patti et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)
Impact of FDA Drug Risk Communications on Health Care Utilization and Health Behaviors A Systematic Review
Stacie B. Dusetzina et al.
MEDICAL CARE (2012)
Twenty years of functional MRI: The science and the stories
Peter A. Bandettini
NEUROIMAGE (2012)
Brain Imaging in Alzheimer Disease
Keith A. Johnson et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
Whole Genome Deep Sequencing of HIV-1 Reveals the Impact of Early Minor Variants Upon Immune Recognition During Acute Infection
Matthew R. Henn et al.
PLOS PATHOGENS (2012)
Meta-Analysis of Multiple Primary Prevention Trials of Cardiovascular Events Using Aspirin
Alfred A. Bartolucci et al.
AMERICAN JOURNAL OF CARDIOLOGY (2011)
Protein kinase biochemistry and drug discovery
Phillip A. Schwartz et al.
BIOORGANIC CHEMISTRY (2011)
Safety and efficacy of bortezomib-melphalan-prednisone-thalidomide followed by bortezomib-thalidomide maintenance (VMPT-VT) versus bortezomib-melphalan-prednisone (VMP) in untreated multiple myeloma patients with renal impairment
Fortunato Morabito et al.
BLOOD (2011)
Trastuzumab-DM1 (T-DM1) retains all the mechanisms of action of trastuzumab and efficiently inhibits growth of lapatinib insensitive breast cancer
Teemu T. Junttila et al.
BREAST CANCER RESEARCH AND TREATMENT (2011)
Metabolomics and Its Practical Value in Pharmaceutical Industry
Ru Wei
CURRENT DRUG METABOLISM (2011)
Depression and Medication Adherence in the Treatment of Chronic Diseases in the United States: A Meta-Analysis
Jerry L. Grenard et al.
JOURNAL OF GENERAL INTERNAL MEDICINE (2011)
Tyrosine kinases in rheumatoid arthritis
Hiroshi Okamoto et al.
JOURNAL OF INFLAMMATION-LONDON (2011)
Believe it or not: how much can we rely on published data on potential drug targets?
Florian Prinz et al.
NATURE REVIEWS DRUG DISCOVERY (2011)
Carbamazepine-Induced Toxic Effects and HLA-B*1502 Screening in Taiwan
Pei Chen et al.
NEW ENGLAND JOURNAL OF MEDICINE (2011)
MicroRNAs in cardiac disease
Gerald W. Dorn
TRANSLATIONAL RESEARCH (2011)
Proteomics and Systems Biology: Current and Future Applications in the Nutritional Sciences
J. Bernadette Moore et al.
ADVANCES IN NUTRITION (2011)
Consumer-oriented interventions for evidence-based prescribing and medicines use: an overview of systematic reviews
Rebecca Ryan et al.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2011)
MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy
Andrea L. Kasinski et al.
NATURE REVIEWS CANCER (2011)
Successes Achieved and Challenges Ahead in Translating Biomarkers into Clinical Applications
Greg Tesch et al.
AAPS Journal (2010)
Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells
D. Eastwood et al.
BRITISH JOURNAL OF PHARMACOLOGY (2010)
IL-6: from its discovery to clinical applications
Tadamitsu Kishimoto
INTERNATIONAL IMMUNOLOGY (2010)
Anti-TNF Therapy, from Rationale to Standard of Care: What Lessons Has It Taught Us?
Marc Feldmann et al.
JOURNAL OF IMMUNOLOGY (2010)
Renal biomarker qualification submission: a dialog between the FDA-EMEA and Predictive Safety Testing Consortium
Frank Dieterle et al.
NATURE BIOTECHNOLOGY (2010)
Use of transcriptomics in understanding mechanisms of drug-induced toxicity
Yuxia Cui et al.
PHARMACOGENOMICS (2010)
The influence of SLCO1B1 (OATP1B1) gene polymorphisms on response to statin therapy
S. P. R. Romaine et al.
PHARMACOGENOMICS JOURNAL (2010)
Small-animal positron emission tomography as a tool for neuropharmacology
Sophie Lancelot et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2010)
Humanized mouse models to study human diseases
Michael A. Brehm et al.
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY (2010)
TIMELINE The grand challenge to decipher the cancer proteome
Samir Hanash et al.
NATURE REVIEWS CANCER (2010)
MicroRNAs: Target Recognition and Regulatory Functions
David P. Bartel
CELL (2009)
Humanized Mice for Modeling Human Infectious Disease: Challenges, Progress, and Outlook
Nicolas Legrand et al.
CELL HOST & MICROBE (2009)
Metabolomic Profiling Reveals Distinct Patterns of Myocardial Substrate Use in Humans With Coronary Artery Disease or Left Ventricular Dysfunction During Surgical Ischemia/Reperfusion
Aslan T. Turer et al.
CIRCULATION (2009)
Approaching clinical proteomics: current state and future fields of application in fluid proteomics
Rolf Apweiler et al.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2009)
Tyrosine-phosphorylation: thirty years and counting
Tony Hunter
CURRENT OPINION IN CELL BIOLOGY (2009)
Imatinib and Its Successors - How Modern Chemistry has Changed Drug Development
Bernhard A. Mueller
CURRENT PHARMACEUTICAL DESIGN (2009)
Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV
Erik De Clercq
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2009)
Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression
Arun Sreekumar et al.
NATURE (2009)
RNA-Seq: a revolutionary tool for transcriptomics
Zhong Wang et al.
NATURE REVIEWS GENETICS (2009)
Metabolomics: A global biochemical approach to drug response and disease
Rima Kaddurah-Daouk et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY (2008)
Cytokine signaling modules in inflammatory responses
John J. O'Shea et al.
IMMUNITY (2008)
Medication adherence after myocardial infarction: A long way left to go
Niteesh K. Choudhry et al.
JOURNAL OF GENERAL INTERNAL MEDICINE (2008)
Tumor necrosis factor antagonist mechanisms of action: A comprehensive review
Daniel Tracey et al.
PHARMACOLOGY & THERAPEUTICS (2008)
Morphological and functional imaging in COPD with CT and MRI: present and future
Julia Ley-Zaporozhan et al.
EUROPEAN RADIOLOGY (2008)
The influence of drug-like concepts on decision-making in medicinal chemistry
Paul D. Leeson et al.
NATURE REVIEWS DRUG DISCOVERY (2007)
Quantitative mass spectrometry in proteomics: a critical review
Marcus Bantscheff et al.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2007)
Drug therapy: Trastuzumab - Mechanism of action and use in clinical practice
Clifford A. Hudis
NEW ENGLAND JOURNAL OF MEDICINE (2007)
Molecular recognition of protein kinase binding pockets for design of potent and selective kinase inhibitors
Jeffrey Jie-Lou Liao
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Humanized mice in translational biomedical research
Leonard D. Shultz et al.
NATURE REVIEWS IMMUNOLOGY (2007)
A decade of fragment-based drug design: strategic advances and lessons learned
Philip J. Hajduk et al.
NATURE REVIEWS DRUG DISCOVERY (2007)
The pleiotropic effects of the SDF-1-CXCR4 axis in organogenesis, regeneration and tumorigenesis
M. Z. Ratajczak et al.
LEUKEMIA (2006)
Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412
Ganesh Suntharalingam et al.
NEW ENGLAND JOURNAL OF MEDICINE (2006)
Protein biomarker discovery and validation: the long and uncertain path to clinical utility
Nader Rifai et al.
NATURE BIOTECHNOLOGY (2006)
History of HAART - the true story of how effective multi-drug therapy was developed for treatment of HIV disease
Martin Delaney
RETROVIROLOGY (2006)
A microscale in vitro physiological model of the liver:: Predictive screens for drug metabolism and enzyme induction
A Sivaraman et al.
CURRENT DRUG METABOLISM (2005)
Why most published research findings are false
JPA Ioannidis
PLOS MEDICINE (2005)
Virtual computational chemistry laboratory - design and description
IV Tetko et al.
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2005)
Automated 20 kpsi RPLC-MS and MS/MS with chromatographic peak capacities of 1000-1500 and capabilities in proteomics and metabolomics
YF Shen et al.
ANALYTICAL CHEMISTRY (2005)
The role of transcriptome analysis in pre-clinical toxicology
GH Searfoss et al.
CURRENT MOLECULAR MEDICINE (2005)
Of mice and not men: Differences between mouse and human immunology
J Mestas et al.
JOURNAL OF IMMUNOLOGY (2004)
Relationship between adherence to inhaled corticosteroids and poor outcomes among adults with asthma
LK Williams et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2004)
Lovastatin and beyond: The history of the HMG-CoA reductase inhibitors
JA Tobert
NATURE REVIEWS DRUG DISCOVERY (2003)
Nonadherence to adjuvant tamoxifen therapy in women with primary breast cancer
AH Partridge et al.
JOURNAL OF CLINICAL ONCOLOGY (2003)
Domain antibodies: proteins for therapy
LJ Holt et al.
TRENDS IN BIOTECHNOLOGY (2003)
The protein kinase complement of the human genome
G Manning et al.
SCIENCE (2002)
Changes in mitochondrial DNA as a marker of nucleoside toxicity in HIV-infected patients
HCF Coté et al.
NEW ENGLAND JOURNAL OF MEDICINE (2002)
High-throughput crystallography for lead discovery in drug design
TL Blundell et al.
NATURE REVIEWS DRUG DISCOVERY (2002)
分享论文
