期刊
BRITISH JOURNAL OF PHARMACOLOGY
卷 171, 期 10, 页码 2593-2607出版社
WILEY
DOI: 10.1111/bph.12538
关键词
asthma; COPD; TRP channels; airway
资金
- Medical Research Council, (MRC) COPD studentship
- MRC, UK [MR/K020293/1]
- MRC [MR/K020293/1] Funding Source: UKRI
- Asthma UK [MRC-AsthmaUKCentre] Funding Source: researchfish
- Medical Research Council [G1000758, G1000758B, MR/K020293/1] Funding Source: researchfish
Over the last few decades, there has been an explosion of scientific publications reporting the many and varied roles of transient receptor potential (TRP) ion channels in physiological and pathological systems throughout the body. The aim of this review is to summarize the existing literature on the role of TRP channels in the lungs and discuss what is known about their function under normal and diseased conditions. The review will focus mainly on the pathogenesis and symptoms of asthma and chronic obstructive pulmonary disease and the role of four members of the TRP family: TRPA1, TRPV1, TRPV4 and TRPM8. We hope that the article will help the reader understand the role of TRP channels in the normal airway and how their function may be changed in the context of respiratory disease.
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