期刊
BRITISH JOURNAL OF PHARMACOLOGY
卷 171, 期 4, 页码 888-895出版社
WILEY
DOI: 10.1111/bph.12419
关键词
BCR; BAFF; MIF; CD74; invariant chain; B cells; survival
In healthy individuals, the pool of peripheral lymphocytes is constant in size. The control of lymphoid homeostasis is the result of a very fine balance between lymphocyte production, survival and proliferation. Survival factors have been shown to play a critical role in maintaining the correct size of lymphocyte populations. Midkine, a heparin-binding cytokine was recently shown to be involved in cell proliferation, differentiation and apoptosis in various cell types including normal and malignant B cells. This review focuses on the role of midkine in the regulation of peripheral B cell survival in health and disease. Linked ArticlesThis article is part of a themed section on Midkine. To view the other articles in this section visit
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