期刊
BRITISH JOURNAL OF PHARMACOLOGY
卷 171, 期 8, 页码 1870-1889出版社
WILEY
DOI: 10.1111/bph.12430
关键词
mitochondria; protease; mitochondrial morphology; protein quality control; neurodegenerative disease; apoptosis
资金
- National Health and Medical Research Council
Progressive mitochondrial dysfunction is linked with the onset of many age-related pathologies and neurological disorders. Mitochondrial damage can come in many forms and be induced by a variety of cellular insults. To preserve organelle function during biogenesis or times of stress, multiple surveillance systems work to ensure the persistence of a functional mitochondrial network. This review provides an overview of these processes, which collectively contribute to the maintenance of a healthy mitochondrial population, which is critical for cell physiology and survival. Linked ArticlesThis article is part of a themed issue on Mitochondrial Pharmacology: Energy, Injury & Beyond. To view the other articles in this issue visit
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