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Heteromultimerization of Cannabinoid CB1 Receptor and Orexin OX1 Receptor Generates a Unique Complex in Which Both Protomers Are Regulated by Orexin A
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Agonist ligand discrimination by the two orexin receptors depends on the expression system
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Dynein Light Chain Tctex-Type 1 Modulates Orexin Signaling through Its Interaction with Orexin 1 Receptor
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Rapid and easy semi-quantitative evaluation method for diacylglycerol and inositol-1,4,5-trisphosphate generation in orexin receptor signalling
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Orexins/hypocretins control bistability of hippocampal long-term synaptic plasticity through co-activation of multiple kinases
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Hypocretin/orexin increases the expression of steroidogenic enzymes in human adrenocortical NCI H295R cells
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Orexin-A increases cell surface expression of AMPA receptors in the striatum
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5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a Phospholipase D Pharmacological Inhibitor That Alters Cell Spreading and Inhibits Chemotaxis
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PIP2 is a necessary cofactor for ion channel function: How and why?
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CELLULAR AND MOLECULAR LIFE SCIENCES (2008)
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Orexins stimulate steroidogenic acute regulatory protein expression through multiple signaling pathways in human adrenal H295R cells
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Orexin A in the VTA is critical for the induction of synaptic plasticity and Behavioral Sensitization to cocaine
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G-protein-coupled OX1 orexin/hcrtr-1 hypocretin receptors induce caspase-dependent and -independent cell death through p38 Mitogen-/Stress-activated protein kinase
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JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
OX1 orexin receptors activate extracellular signal-regulated kinase in Chinese hamster ovary cells via multiple mechanisms: The role of Ca2+ influx in OX1 receptor signaling
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Cholecystokinin activates orexin/hypocretin neurons through the cholecystokinin A receptor
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Food deprivation differentially modulates orexin receptor expression and signaling in rat hypothalamus and adrenal cortex
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The sustainability of interactions between the orexin-1 receptor and β-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of ERK MAPK regulation
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Effects of orexins/hypocretins on neuronal activity in the paraventricular nucleus of the thalamus in rats in vitro
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TRENDS IN PHARMACOLOGICAL SCIENCES (2005)
OX1 orexin receptors couple to adenylyl cyclase regulation via multiple mechanisms
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The wake-promoting peptide orexin-B inhibits glutamatergic transmission to dorsal raphe nucleus serotonin neurons through retrograde endocannabinoid signaling
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Orexin-A-induced Ca2+ entry -: Evidence for involvement of TRPC channels and protein kinase C regulation
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Cellular regulation and proposed biological functions of group VIA calcium-independent phospholipase A(2) in activated cells
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Hypocretin/orexin innervation and excitation of identified septohippocampal cholinergic neurons
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Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system
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Orexins (hypocretins) directly interact with neuropeptide YPOMC and glucose-responsive neurons to regulate Ca2+ signaling in a reciprocal manner to leptin:: orexigenic neuronal pathways in the mediobasal hypothalamus
S Muroya et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2004)
Regulation of receptor-coupling to (multiple) G proteins. A challenge for basic research and drug discovery
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Orexin (hypocretin) effects on constitutively active inward rectifier K+ channels in cultured nucleus basalis neurons
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JOURNAL OF NEUROPHYSIOLOGY (2004)
Hypocretin/orexin peptide signaling in the ascending arousal system: Elevation of intracellular calcium in the mouse dorsal raphe and laterodorsal tegmentum
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Orexins/hypocretins cause sharp wave- and theta-related synaptic plasticity in the hippocampus via glutamatergic, gabaergic, noradrenergic, and cholinergic signaling
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Orexins acting at native OX1 receptor in colon cancer and neuroblastoma cells or at recombinant OX1 receptor suppress cell growth by inducing apoptosis
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JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Hypocretin-1 causes G protein activation and increases ACh release in rat pons
R Bernard et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2003)
Hypocretin (orexin) induces calcium transients in single spines postsynaptic to identified thalamocortical boutons in prefrontal slice
EK Lambe et al.
NEURON (2003)
The STC-1 cells express functional orexin-A receptors coupled to CCK release
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Effects of orexin (hypocretin) on GIRK channels
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JOURNAL OF NEUROPHYSIOLOGY (2003)
Gating of GIRK channels: Details of an intricate, membrane-delimited signaling complex
R Sadja et al.
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Phosphoinositide 3-kinase signalling - which way to target?
MP Wymann et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2003)
Hypersensitization of the orexin 1 receptor by the CB1 receptor -: Evidence for cross-talk blocked by the specific CB1 antagonist, SR141716
S Hilairet et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Hypocretin/orexin excites hypocretin neurons via a local glutamate neuron - A potential mechanism for orchestrating the hypothalamic arousal system
Y Li et al.
NEURON (2002)
Orexin-A augments voltage-gated Ca2+ currents and synergistically increases growth hormone (GH) secretion with GH-releasing hormone in primary cultured ovine somatotropes
RW Xu et al.
ENDOCRINOLOGY (2002)
Orexin signaling in recombinant neuron-like cells
T Holmqvist et al.
FEBS LETTERS (2002)
Characterization of a novel inhibitor of cytosolic phospholipase A2α, pyrrophenone
T Ono et al.
BIOCHEMICAL JOURNAL (2002)
Hypocretin-I activates G proteins in arousal-related brainstem nuclei of rat
R Bernard et al.
NEUROREPORT (2002)
Selective excitation of GABAergic neurons in the substantia nigra of the rat by orexin/hypocretin in vitro
TM Korotkova et al.
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Selective enhancement of excitatory synaptic activity in the rat nucleus tractus solitarius by hypocretin 2
BN Smith et al.
NEUROSCIENCE (2002)
Orexin receptors couple to Ca2+ channels different from stove-operated Ca2+ channels
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NEUROREPORT (2001)
Orexin-a activates phospholipase C- and protein kinase C-mediated Ca2+ signaling in dopamine neurons of the ventral tegmental area
K Uramura et al.
NEUROREPORT (2001)
Lateral hypothalamus: Early developmental expression and response to hypocretin (orexin)
AN van den Pol et al.
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Visualizing differences in ligand-induced β-arrestin-GFP interactions and trafficking between three recently characterized G protein-coupled receptors
NA Evans et al.
JOURNAL OF NEUROCHEMISTRY (2001)
The orexin OX1 receptor activates a novel Ca2+ influx pathway necessary for coupling to phospholipase C
PE Lund et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)