相关参考文献
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Stephen P. H. Alexander et al.
BRITISH JOURNAL OF PHARMACOLOGY (2011)
Design, Synthesis, and Biological Activity of Potent and Orally Available G Protein-Coupled Receptor 40 Agonists
Shinobu Sasaki et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
TAK-875, an Orally Available G Protein-Coupled Receptor 40/Free Fatty Acid Receptor 1 Agonist, Enhances Glucose-Dependent Insulin Secretion and Improves Both Postprandial and Fasting Hyperglycemia in Type 2 Diabetic Rats
Yoshiyuki Tsujihata et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2011)
Molecular docking and molecular dynamics simulation studies of GPR40 receptor-agonist interactions
Shao-Yong Lu et al.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2010)
Structure-Activity Relationships of GPR120 Agonists Based on a Docking Simulation
Qi Sun et al.
MOLECULAR PHARMACOLOGY (2010)
The structure and function of G-protein-coupled receptors
Daniel M. Rosenbaum et al.
NATURE (2009)
Novel selective ligands for free fatty acid receptors GPR120 and GPR40
Takafumi Hara et al.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2009)
Flow Cytometry-Based Binding Assay for GPR40 ( FFAR1; Free Fatty Acid Receptor 1)
Takafumi Hara et al.
MOLECULAR PHARMACOLOGY (2009)
Free fatty acid receptors and drug discovery
Akira Hirasawa et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2008)
Discovery of diacylphloroglucinols as a new class of GPR40 (FFAR1) agonists
Sandip B. Bharate et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
One-pot approach for the synthesis of trans-cyclopropyl compounds from aldehydes. Application to the synthesis of GPR40 receptor agonists
Michael Davi et al.
CHEMICAL COMMUNICATIONS (2008)
Homology model-based virtual screening for GPCR ligands using docking and target-biased scoring
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JOURNAL OF CHEMICAL INFORMATION AND MODELING (2008)
Identification of G protein-coupled receptor 120-selective agonists derived from PPARγ agonists
Takayoshi Suzuki et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
International Union of Pharmacology. LXXI. Free Fatty Acid Receptors FFA1,-2, and-3: Pharmacology and Pathophysiological Functions
Leigh A. Stoddart et al.
PHARMACOLOGICAL REVIEWS (2008)
Identification of residues important for agonist recognition and activation in GPR40
Chi Shing Sum et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Bidirectional, iterative approach to the structural delineation of the functional Chemoprint in GPR40 for agonist recognition
Irina G. Tikhonova et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
G protein coupled receptor structure and activation
Brian K. Kobilka
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2007)
Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules
Celia P. Briscoe et al.
BRITISH JOURNAL OF PHARMACOLOGY (2006)
MolDock: A new technique for high-accuracy molecular docking
Rene Thomsen et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Synthesis and activity of small molecule GPR40 agonists
DM Garrido et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
Molecular evolution of adrenoceptors and dopamine receptors:: Implications for the binding of catecholamines
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JOURNAL OF MEDICINAL CHEMISTRY (2006)
Reduction in voltage-gated K+ currents in primary cultured rat pancreatic β-cells by linoleic acids
DD Feng et al.
ENDOCRINOLOGY (2006)
G protein-coupled receptors for free fatty acids
Graeme Milligan et al.
CELLULAR SIGNALLING (2006)
The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse
R Steneberg et al.
CELL METABOLISM (2005)
Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120
A Hirasawa et al.
NATURE MEDICINE (2005)
Structural models of the photointermediates in the rhodopsin photocascade, lumirhodopsin, metarhodopsin I, and metarhodopsin II
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CHEMBIOCHEM (2004)
PPAR-γ overexpression suppresses glucose-induced proinsulin biosynthesis and insulin release synergistically with pioglitazone in MIN6 cells
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
The ins and outs of fatty acids on the pancreatic β cell
V Poitout
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2003)
The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids
CP Briscoe et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40
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NATURE (2003)
Homology model of the CB1 cannabinoid receptor: Sites critical for nonclassical cannabinoid agonist interaction
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BIOPOLYMERS (2003)