相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Combining Quantum Mechanical Ligand Conformation Analysis and Protein Modeling to Elucidate GPCR-Ligand Binding Modes
Sabine Schultes et al.
CHEMMEDCHEM (2013)
Mapping histamine H-4 receptor-ligand binding modes
Sabine Schultes et al.
MEDCHEMCOMM (2013)
Ligand based design of novel histamine H4 receptor antagonists; fragment optimization and analysis of binding kinetics
Rogier A. Smits et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Molecular Determinants of Selective Agonist and Antagonist Binding to the Histamine H4 Receptor
Enade P. Istyastono et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2012)
Molecular pharmacology of histamine H4 receptors
Saskia Nijmeijer et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2012)
Crystal structure of the μ-opioid receptor bound to a morphinan antagonist
Aashish Manglik et al.
NATURE (2012)
Analysis of Multiple Histamine H4 Receptor Compound Classes Uncovers Gαi Protein- and β-Arrestin2-Biased Ligands
Saskia Nijmeijer et al.
MOLECULAR PHARMACOLOGY (2012)
Irreversible Protein Kinase Inhibitors
L. Garuti et al.
CURRENT MEDICINAL CHEMISTRY (2011)
Triazole Ligands Reveal Distinct Molecular Features That Induce Histamine H4 Receptor Affinity and Subtly Govern H4/H3 Subtype Selectivity
Maikel Wijtmans et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Molecular Determinants of Ligand Binding Modes in the Histamine H4 Receptor: Linking Ligand-Based Three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) Models to in Silico Guided Receptor Mutagenesis Studies
Enade P. Istyastono et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Mass Spectrometry-based Proteomics of Human Cannabinoid Receptor 2: Covalent Cysteine 6.47(257)-Ligand Interaction Affording Megagonist Receptor Activation
Dennis W. Szymanski et al.
JOURNAL OF PROTEOME RESEARCH (2011)
Agonist-Biased Signaling at the Histamine H4 Receptor: JNJ7777120 Recruits β-Arrestin without Activating G Proteins
Elizabeth M. Rosethorne et al.
MOLECULAR PHARMACOLOGY (2011)
Structure of the human histamine H1 receptor complex with doxepin
Tatsuro Shimamura et al.
NATURE (2011)
Structure and function of an irreversible agonist-β2 adrenoceptor complex
Daniel M. Rosenbaum et al.
NATURE (2011)
En route to new blockbuster anti-histamines: surveying the offspring of the expanding histamine receptor family
Rob Leurs et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2011)
hCB2 Ligand-Interaction Landscape: Cysteine Residues Critical to Biarylpyrazole Antagonist Binding Motif and Receptor Modulation
Richard W. Mercier et al.
CHEMISTRY & BIOLOGY (2010)
A Lipid Pathway for Ligand Binding Is Necessary for a Cannabinoid G Protein-coupled Receptor
Dow P. Hurst et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
The Epstein-Barr Virus-encoded G Protein-coupled Receptor BILF1 Hetero-oligomerizes with Human CXCR4, Scavenges Gαi Proteins, and Constitutively Impairs CXCR4 Functioning
Saskia Nijmeijer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Synthesis and QSAR of Quinazoline Sulfonamides As Highly Potent Human Histamine H4 Receptor Inverse Agonists
Rogier A. Smits et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Interactions of the Melanocortin-4 Receptor with the Peptide Agonist NDP-MSH
Kathryn L. Chapman et al.
JOURNAL OF MOLECULAR BIOLOGY (2010)
Molecular Determinants of Ligand Binding to H4R Species Variants
Herman D. Lim et al.
MOLECULAR PHARMACOLOGY (2010)
2,4-Diaminopyrimidines as histamine H4 receptor ligands-Scaffold optimization and pharmacological characterization
Kerstin Sander et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2009)
Major advances in the development of histamine H4 receptor ligands
Rogier A. Smits et al.
DRUG DISCOVERY TODAY (2009)
Covalent Modifiers: An Orthogonal Approach to Drug Design
Michele H. Potashman et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Dopamine D2 receptors form higher order oligomers at physiological expression levels
Wen Guo et al.
EMBO JOURNAL (2008)
Delineation of agonist binding to the human histamine H4 receptor using mutational analysis, homology modeling, and ab initio calculations
Aldo Jongejan et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2008)
Discovery of Quinazolines as Histamine H4 Receptor Inverse Agonists Using a Scaffold Hopping Approach
Rogier A. Smits et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Molecular modeling of the second extracellular loop of G-protein coupled receptors and its implication on structure-based virtual screening
Chris de Graaf et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2008)
High-resolution crystal structure of an engineered human β2-adrenergic G protein-coupled receptor
Vadim Cherezov et al.
SCIENCE (2007)
Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase
Zhengying Pan et al.
CHEMMEDCHEM (2007)
Determining the potency and molecular mechanism of action of insurmountable antagonists
Terry Kenakin et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)
Tyrosine kinase inhibitors.: 19.: 6-alkynamides of 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as irreversible inhibitors of the erbB family of tyrosine kinase receptors
SR Klutchko et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
A chemogenomic analysis of the transmembrane binding cavity of human G-protein-coupled receptors
JS Surgand et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2006)
Linking agonist binding to histamine H1 receptor activation
A Jongejan et al.
NATURE CHEMICAL BIOLOGY (2005)
(S)-(2-(2′-pyridyl)ethyl)cysteamine and (S)(2-(2′-pyridyl)ethyl)-D,L-homocysteine as ligands for the fac-[M(CO)3]+ (M = Re, 99mTc) Core
O Karagiorgou et al.
INORGANIC CHEMISTRY (2005)
Optimization of 6,7-disubstituted-4-(arylamino)quinoline-3-carbonitriles as orally active, irreversible inhibitors of human epidermal growth factor receptor-2 kinase activity
HR Tsou et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Site-specific disulfide capture of agonist and antagonist peptides on the C5a receptor
E Buck et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Aza-peptide Michael acceptors:: A new class of inhibitors specific for caspases and other clan CD cysteine proteases
OD Ekici et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
The first potent and selective non-imidazole human histamine H4 receptor antagonists
JA Jablonowski et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
Modulation of agonist responses at the A1 adenosine receptor by an irreversible antagonist, receptor-G protein uncoupling and by the G protein activation state
A Lorenzen et al.
BIOCHEMICAL PHARMACOLOGY (2002)
Phenoxybenzamine binding reveals the helical orientation of the third transmembrane domain of adrenergic receptors
H Frang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Crystal structure of rhodopsin: A G protein-coupled receptor
K Palczewski et al.
SCIENCE (2000)
分享论文
