期刊
BRITISH JOURNAL OF PHARMACOLOGY
卷 167, 期 2, 页码 313-323出版社
WILEY
DOI: 10.1111/j.1476-5381.2012.02042.x
关键词
atherosclerosis; restenosis; neointima; myocardial infarction and reperfusion injury; stroke; macrophages; smooth muscle cells; endothelial cells
资金
- Swiss National Science Foundation [310030_130732_1]
- Bangerter Rhyner
- OPO
- Novartis
- Swiss Life foundation
- Intramural Research Program of NIH/NIAAA
- Swiss National Science Foundation (SNF) [310030_130732] Funding Source: Swiss National Science Foundation (SNF)
Cardiovascular disease is the leading cause of death and disability worldwide, which can be largely attributed to atherosclerosis, a chronic inflammation of the arteries characterized by lesions containing immune and smooth muscle cells, lipids and extracellular matrix. In recent years, the lipid endocannabinoid system has emerged as a new therapeutic target in variety of disorders associated with inflammation and tissue injury, including those of the cardiovascular system. The discovery that ?-9-tetrahydrocannabinol (?9-THC), the main active constituent of marijuana, inhibited atherosclerotic plaque progression via a cannabinoid 2 (CB2) receptor-dependent anti-inflammatory mechanism, and that certain natural and synthetic cannabinoid ligands could modulate the myocardial or cerebral ischaemiareperfusion-induced tissue damage, have stimulated impetus for a growing number of studies investigating the implication of CB2 receptors in atherosclerosis, restenosis, stroke, myocardial infarction and heart failure. The aim of this review is to update on recent findings and controversies on the role of CB2 receptors in cardiovascular disease. Particular emphasis will be placed on novel insights in the potential cellular targets of CB2 stimulation in cardiovascular system (e.g. endothelial and vascular smooth muscle cells, cardiomyocytes, infiltrating and/or resident monocytes/macrophages and leukocytes, etc.), their interplay and intracellular signalling mechanisms identified, as well as on experimental and clinical studies.
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