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Alain Couvineau et al.
BRITISH JOURNAL OF PHARMACOLOGY (2012)
Calcitonin and calcitonin receptor-like receptors: common themes with family B GPCRs?
James Barwell et al.
BRITISH JOURNAL OF PHARMACOLOGY (2012)
Consequences of splice variation on Secretin family G protein-coupled receptor function
Sebastian G. B. Furness et al.
BRITISH JOURNAL OF PHARMACOLOGY (2012)
The Family B1 GPCR: Structural Aspects and Interaction with Accessory Proteins
Alain Couvineau et al.
CURRENT DRUG TARGETS (2012)
Mice Deficient in Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) are More Susceptible to Retinal Ischemic Injury In Vivo
K. Szabadfi et al.
NEUROTOXICITY RESEARCH (2012)
Temporal phasing of locomotor activity, heart rate rhythmicity, and core body temperature is disrupted in VIP receptor 2-deficient mice
Jens Hannibal et al.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2011)
Copy Number Variants in Schizophrenia: Confirmation of Five Previous Findings and New Evidence for 3q29 Microdeletions and VIPR2 Duplications
Douglas F. Levinson et al.
AMERICAN JOURNAL OF PSYCHIATRY (2011)
Identification by photoaffinity labeling of the extracellular N-terminal domain of PAC1 receptor as the major binding site for PACAP
Agnieszka Dejda et al.
BIOCHIMIE (2011)
Special Issue: Guide to Receptors and Channels, 5th Edition Abstracts
Stephen P. H. Alexander et al.
BRITISH JOURNAL OF PHARMACOLOGY (2011)
NAP (Davunetide) Provides Functional and Structural Neuroprotection
Illana Gozes
CURRENT PHARMACEUTICAL DESIGN (2011)
SCHIZOPHRENIA Zooming in on a gene
Hugh D. Piggins
NATURE (2011)
Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor
Kerry J. Ressler et al.
NATURE (2011)
Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia
Vladimir Vacic et al.
NATURE (2011)
IUPHAR-DB: new receptors and tools for easy searching and visualization of pharmacological data
Joanna L. Sharman et al.
NUCLEIC ACIDS RESEARCH (2011)
Characterization of Intestinal and Pancreatic Dysfunction in VPAC1-Null Mutant Mouse
Dorit Fabricius et al.
PANCREAS (2011)
Crystal Structure of the PAC1R Extracellular Domain Unifies a Consensus Fold for Hormone Recognition by Class B G-Protein Coupled Receptors
Shiva Kumar et al.
PLOS ONE (2011)
PACAP centrally mediates emotional stress-induced corticosterone responses in mice
Naohiro Tsukiyama et al.
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS (2011)
Roles for Pituitary Adenylate Cyclase-Activating Peptide (PACAP) Expression and Signaling in the Bed Nucleus of the Stria Terminalis (BNST) in Mediating the Behavioral Consequences of Chronic Stress
Sayamwong E. Hammack et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2010)
Identification and Characterization of a Small Molecule Antagonist of Human VPAC(2) Receptor
Alan Chu et al.
MOLECULAR PHARMACOLOGY (2010)
STRESS HORMONE SYNTHESIS IN MOUSE HYPOTHALAMUS AND ADRENAL GLAND TRIGGERED BY RESTRAINT IS DEPENDENT ON PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE SIGNALING
N. Stroth et al.
NEUROSCIENCE (2010)
Vasoactive intestinal peptide loss leads to impaired CNS parenchymal T-cell infiltration and resistance to experimental autoimmune encephalomyelitis
Catalina Abad et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Molecular and Conformational Determinants of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) for Activation of the PAC1 Receptor
Steve Bourgault et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
PACAP Neurons in the Hypothalamic Ventromedial Nucleus Are Targets of Central Leptin Signaling
Zoe Hawke et al.
JOURNAL OF NEUROSCIENCE (2009)
Pituitary Adenylate Cyclase-Activating Polypeptide Inhibits Food Intake in Mice Through Activation of the Hypothalamic Melanocortin System
Lourdes Mounien et al.
NEUROPSYCHOPHARMACOLOGY (2009)
Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery
D. Vaudry et al.
PHARMACOLOGICAL REVIEWS (2009)
VPAC and PAC receptors: From ligands to function
Louise Dickson et al.
PHARMACOLOGY & THERAPEUTICS (2009)
Pituitary adenylyl cyclase-activating polypeptide is an intrinsic regulator of Treg abundance and protects against experimental autoimmune encephalomyelitis
Yossan-Var Tan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
The Neurotransmitter VIP Expands the Pool of Symmetrically Dividing Postnatal Dentate Gyrus Precursors via VPAC2 Receptors or Directs Them Toward a Neuronal Fate via VPAC1 Receptors
Malik Zaben et al.
STEM CELLS (2009)
Metabolic rhythm abnormalities in mice lacking VIP-VPAC2 signaling
David A. Bechtold et al.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2008)
Mice lacking the PACAP type I receptor have impaired photic entrainment and negative masking
Jens Hannibal et al.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2008)
Discovery and SAR of hydrazide antagonists of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor type 1 (PAC1-R)
Xenia Beebe et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
PACAP prevents toxicity induced by cisplatin in rat and primate neurons but not in proliferating ovary cells: Involvement of the mitochondrial apoptotic pathway
Nicolas Aubert et al.
NEUROBIOLOGY OF DISEASE (2008)
Class-B GPCR activation:: is ligand helix-capping the key?
Jean-Michel Neumann et al.
TRENDS IN BIOCHEMICAL SCIENCES (2008)
Gastrointestinal dysfunction in mice with a targeted mutation in the gene encoding vasoactive intestinal polypeptide: A model for the study of. intestinal ileus and Hirschsprung's disease
V. Lelievre et al.
PEPTIDES (2007)
Class II G protein-coupled receptors for VIP and PACAP: Structure, models of activation and pharmacology
Marc Laburthe et al.
PEPTIDES (2007)
Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-Rs
Chaohong Sun et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
A systematic comparison of intracellular cyclic AMP and calcium signalling highlights complexities in VPAC/PAC receptor pharmacology
Louise Dickson et al.
NEUROPHARMACOLOGY (2006)
Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6
Hirokazu Ohtaki et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Peptide agonist docking in the N-terminal ectodomain of a class II G protein-coupled receptor, the VPAC1 receptor -: Photoaffinity, NMR, and molecular modeling
YV Tan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Therapeutic effect of vasoactive intestinal peptide on experimental autoimmune encephalomyelitis - Down-regulation of inflammatory and autoimmune responses
E Gonzalez-Rey et al.
AMERICAN JOURNAL OF PATHOLOGY (2006)
VPAC2 receptors mediate vasoactive intestinal peptide-induced neuroprotection against neonatal excitotoxic brain lesions in mice
CM Rangon et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
Aberrant gating of photic input to the suprachiasmatic circadian pacemaker of mice lacking the VPAC2 receptor
AT Hughes et al.
JOURNAL OF NEUROSCIENCE (2004)
Vasoactive intestinal peptide modulates proinflammatory mediator synthesis in osteoarthritic and rheumatoid synovial cells
MG Juarranz et al.
RHEUMATOLOGY (2004)
Distribution of the VPAC2 receptor in peripheral tissues of the mouse
AJ Harmar et al.
ENDOCRINOLOGY (2004)
NMR structure and peptide hormone binding site of the first extracellular domain of a type B1 G protein-coupled receptor
CRR Grace et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Pituitary adenylate cyclase-activating polypeptide is required for the development of spinal sensitization and induction of neuropathic pain
T Mabuchi et al.
JOURNAL OF NEUROSCIENCE (2004)
Differential regulation of activity-dependent neuroprotective protein in rat astrocytes by VIP and PACAP
M Zusev et al.
REGULATORY PEPTIDES (2004)
The multiple mediators of neurogenic smooth muscle relaxation
SI Said et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2004)
Pulmonary hypertension and right heart failure in pituitary adenylate cyclase-activating polypeptide type I receptor-deficient mice
C Otto et al.
CIRCULATION (2004)
High expression of peptide receptors as a novel target in gastrointestinal stromal tumours
JC Reubi et al.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2004)
Selective deficits in the circadian light response in mice lacking PACAP
CS Colwell et al.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2004)
Overexpression of pituitary adenylate cyclase-activating polypeptide in islets inhibits hyperinsulinemia and islet hyperplasia in agouti yellow mice
S Tomimoto et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2004)
Impaired long-term potentiation in vivo in the dentate gyrus of pituitary adenylate cyclase-activating polypeptide (PACAP) or PACAP type 1 receptor-mutant mice
S Matsuyama et al.
NEUROREPORT (2003)
Disrupted circadian rhythms in VIP- and PHI-deficient mice
CS Colwell et al.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2003)
Changes in light-induced phase shift of circadian rhythm in mice lacking PACAP
C Kawaguchi et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Overexpression of PACAP in transgenic mouse pancreatic β-cells enhances insulin secretion and ameliorates streptozotocin-induced diabetes
K Yamamoto et al.
DIABETES (2003)
Pituitary adenylate cyclase-activating polypeptide prevents C2-ceramide-induced apoptosis of cerebellar granule cells
D Vaudry et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2003)
Therapeutic effects of vasoactive intestinal peptide in the trinitrobenzene sulfonic acid mice model of Crohn's disease
C Abad et al.
GASTROENTEROLOGY (2003)
Novel receptor partners and function of receptor activity-modifying proteins
A Christopoulos et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
The mouse VPAC(2) receptor confers suprachiasmatic nuclei cellular rhythmicity and responsiveness to vasoactive intestinal polypeptide in vitro
DJ Cutler et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2003)
Roles of vasoactive intestinal peptide (VIP) in the expression of different immune phenotypes by wild-type mice and T cell-targeted type 11 VIP receptor Transgenic mice
JK Voice et al.
JOURNAL OF IMMUNOLOGY (2003)
Immunoeffector and immunoregulatory activities of vasoactive intestinal peptide
JK Voice et al.
REGULATORY PEPTIDES (2002)
Molecular pharmacology and structure of VPAC receptors for VIP and PACAP
M Laburthe et al.
REGULATORY PEPTIDES (2002)
Vasoactive intestinal polypeptide/pituitary adenylate cyclase-activating peptide receptor 2 deficiency in mice results in growth retardation and increased basal metabolic rate
MA Asnicar et al.
ENDOCRINOLOGY (2002)
Expression of pituitary adenylate cyclase-activating polypeptide and PACAP type 1 receptor in the rat gastric and colonic myenteric neurons
M Miampamba et al.
REGULATORY PEPTIDES (2002)
The VPAC2 receptor is essential for circadian function in the mouse suprachiasmatic nuclei
AJ Harmar et al.
CELL (2002)
PACAP protects cerebellar granule neurons against oxidative stress-induced apoptosis
D Vaudry et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2002)
A potent and highly selective VPAC2 agonist enhances glucose-induced insulin release and glucose disposal - A potential therapy for type 2 diabetes
M Tsutsumi et al.
DIABETES (2002)
The neuropeptide PACAP contributes to the glucagon response to insulin-induced hypoglycaemia in mice
K Persson et al.
ACTA PHYSIOLOGICA SCANDINAVICA (2002)
Pituitary adenylate cyclase-activating polypeptide protects rat cerebellar granule neurons against ethanol-induced apoptotic cell death
D Vaudry et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Identification of a potential receptor for both peptide histidine isoleucine and peptide histidine valine
DLY Tse et al.
ENDOCRINOLOGY (2002)
Anti-inflammatory role in septic shock of pituitary adenylate cyclase-activating polypeptide receptor
C Martinez et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Pituitary adenylate cyclase-activating polypeptide is a sympathoadrenal neurotransmitter involved in catecholamine regulation and glucohomeostasis
C Hamelink et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Enhanced delayed-type hypersensitivity and diminished immediate-type hypersensitivity in mice lacking the inducible VPAC2 receptor for vasoactive intestinal peptide
EJ Goetzl et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Allergic diathesis in transgenic mice with constitutive T cell expression of inducible vasoactive intestinal peptide receptor
JK Voice et al.
FASEB JOURNAL (2001)
Altered emotional behavior in PACAP-type-I-receptor-deficient mice
C Otto et al.
MOLECULAR BRAIN RESEARCH (2001)
Markedly reduced chronic nociceptive response in mice lacking the PACI receptor
H Jongsma et al.
NEUROREPORT (2001)
Novel alternatively spliced exon in the extracellular ligand-binding domain of the pituitary adenylate cyclase-activating polypeptide (PACAP) type 1 receptor (PAC1R) selectively increases ligand affinity and alters signal transduction coupling during spermatogenesis
PB Daniel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Maxadilan specifically interacts with PAC1 receptor, which is a dominant form of PACAP/VIP family receptors in cultured rat cortical neurons
I Tatsuno et al.
BRAIN RESEARCH (2001)
Localization of the pituitary adenylate cyclase-activating polypeptide receptor and its mRNA in the rat adrenal medulla
S Shioda et al.
NEUROSCIENCE LETTERS (2000)
The neuroprotective effect of pituitary adenylate cyclase-activating polypeptide on cerebellar granule cells is mediated through inhibition of the CED3-related cysteine protease caspase-3/CPP32
D Vaudry et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Development of selective agonists and antagonists for the human vasoactive intestinal polypeptide VPAC2 receptor
D Moreno et al.
PEPTIDES (2000)
Identification of key residues for interaction of vasoactive intestinal peptide with human VPAC1 and VPAC2 receptors and development of a highly selective VPAC1 receptor agonist -: Alanine scanning and molecular modeling of the peptide
P Nicole et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
PAC1 receptor-deficient mice display impaired insulinotropic response to glucose and reduced glucose tolerance
F Jamen et al.
JOURNAL OF CLINICAL INVESTIGATION (2000)
Alteration of PACAP distribution and PACAP receptor binding in the rat sensory nervous system following sciatic nerve transection
H Jongsma et al.
BRAIN RESEARCH (2000)