期刊
BRITISH JOURNAL OF PHARMACOLOGY
卷 166, 期 2, 页码 510-521出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1476-5381.2012.01851.x
关键词
TRPV1; TRPA1; capsaicin; non-neuronal; expression; functionality
资金
- Arthritis Research UK [19296]
- Capacity Building Award in Integrative Mammalian Biology
- BBSRC
- BPS
- HEFCE
- KTN
- MRC
- SFC
- Biotechnology and Biological Sciences Research Council [BB/E527098/1] Funding Source: researchfish
- Versus Arthritis [19296] Funding Source: researchfish
- BBSRC [BB/E527098/1] Funding Source: UKRI
The transient receptor potential vanilloid 1 and ankyrin 1 (TRPV1 and TRPA1, respectively) channels are members of the TRP superfamily of structurally related, non-selective cation channels. It is rapidly becoming clear that the functions of TRPV1 and TRPA1 interlink with each other to a considerable extent. This is especially clear in relation to pain and neurogenic inflammation where TRPV1 is coexpressed on the vast majority of TRPA1-expressing sensory nerves and both integrate a variety of noxious stimuli. The more recent discovery that both TRPV1 and TRPA1 are expressed on a multitude of non-neuronal sites has led to a plethora of research into possible functions of these receptors. Non-neuronal cells on which TRPV1 and TRPA1 are expressed vary from vascular smooth muscle to keratinocytes and endothelium. This review will discuss the expression, functionality and roles of these non-neuronal TRP channels away from sensory nerves to demonstrate the diverse nature of TRPV1 and TRPA1 in addition to a direct role in pain and neurogenic inflammation.
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