期刊
BRITISH JOURNAL OF PHARMACOLOGY
卷 165, 期 7, 页码 2034-2043出版社
WILEY
DOI: 10.1111/j.1476-5381.2011.01691.x
关键词
review article; cardiovascular pharmacology; methods and techniques; myocardial infarction; cyclosporin; reperfusion injury; pre-clinical; animal studies
资金
- University of Glasgow
- Scottish Funding Council
- British Heart Foundation
- Chief Scientist Office, Medical Research Counci
- Medical Research Scotland
- Chief Scientist Office [SCD/01] Funding Source: researchfish
Cyclosporin is an immunosuppressant that has recently been proposed as a treatment to prevent reperfusion injury in acute myocardial infarction (MI). We aimed to determine the overall efficacy of cyclosporin in experimental studies of acute reperfused MI. We conducted a systematic review and stratified meta-analysis of published studies describing the efficacy of cyclosporin in experimental models of acute reperfused MI. We included all in vivo publications of cyclosporin where infarct size was measured. A literature search identified 29 potential studies of which 20 fulfilled the eligibility criteria. In these studies (involving four species of animals), cyclosporin reduced myocardial infarct size by a standardized mean (95% confidence interval) difference of -1.60 (-2.17, -1.03) compared with controls. Cyclosporin failed to demonstrate a convincing benefit in studies involving pigs. Despite this observation, the overall efficacy of cyclosporin did not differ across species (P= 0.358). The dose of cyclosporin given did not affect final infarct size (P= 0.203). Funnel plots of these data suggested heterogeneity among the studies. Cyclosporin had variable effects on infarct size compared with placebo. Cyclosporin had no effect on myocardial infarct size in swine, raising a question over the potential cardioprotective effects of cyclosporin in man.
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