期刊
BRITISH JOURNAL OF PHARMACOLOGY
卷 165, 期 1, 页码 223-234出版社
WILEY
DOI: 10.1111/j.1476-5381.2011.01546.x
关键词
intermediate-conductance calcium-activated potassium channel; small-conductance calcium-activated potassium channel; endothelium-derived hyperpolarizing factor; SKA-31; blood pressure; hypertension
资金
- Novo Nordisk Fonden
- Deutsche Forschungsgemeinschaft [KO1899/10-1]
- NIH [R01GM076063-04S1]
BACKGROUND AND PURPOSE In rodents, the endothelial KCa channels, KCa3.1 and KCa2.3, have been shown to play a crucial role in initiating endothelium-derived hyperpolarizing factor (EDHF) vasodilator responses. However, it is not known to what extent these channels are involved in blood pressure regulation in large mammals, which would also allow us to address safety issues. We therefore characterized canine endothelial KCa3.1 and KCa2.3 functions and evaluated the effect of the KCa3.1/KCa2.3 activator SKA-31 on blood pressure and heart rate in dogs.
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