期刊
BRITISH JOURNAL OF PHARMACOLOGY
卷 164, 期 7, 页码 1829-1844出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1476-5381.2011.01475.x
关键词
morphine; B-cells; T-cells; thymus; bone marrow; homeostatic proliferation; B-cell development; T-cell development
资金
- National Institutes of Health COBRE of the National Center for Research Resource [P20 RR016443]
- National Institutes of Health [DA024962]
- KUMC
BACKGROUND AND PURPOSE EXPERIMENTAL APPROACH Mice were implanted with morphine pellets and B- and T-cell subsets in the bone marrow, thymus, spleen and lymph nodes were analysed at various time points. We also examined the effects of morphine on T-cell development using an ex vivo assay. KEY RESULTS The lymphocyte populations most susceptible to morphine-induced depletion were the precursor cells undergoing selection. As the lymphocytes recovered, more lymphocyte precursors proliferated than in control mice. In addition, peripheral T-cells displayed evidence that they had undergone homeostatic proliferation during the recovery phase of the experiments. CONCLUSIONS AND IMPLICATIONS The recovery of lymphocytes following morphine-induced depletion occurred in the presence of morphine and via increased proliferation of lymphoid precursors and homeostatic proliferation of T-cells.Opioid use and abuse has been linked to significant immunosuppression, which has been attributed, in part, to drug-induced depletion of lymphocytes. We sought to define the mechanisms by which lymphocyte populations are depleted and recover following morphine treatment in mice.
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