期刊
JOURNAL OF CONTROLLED RELEASE
卷 209, 期 -, 页码 139-149出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2015.04.027
关键词
Microbubble; Liposome; Oxygen; Nitric oxide; Xenon; Ultrasound
资金
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1409972] Funding Source: National Science Foundation
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [1059726] Funding Source: National Science Foundation
Gaseous molecules including nitric oxide, hydrogen sulfide, carbon monoxide and oxygen mediate numerous cell signaling pathways and have important physiological roles. Several noble gasses have been shown to elicit biological responses. These bioactive gasses hold great therapeutic potential, however, their controlled delivery remains a significant challenge. Recently, researchers have begun using microbubbles and liposomes to encapsulate such gasses for parenteral delivery. The resultant particles are acoustically active, and ultrasound can be used to stimulate and/or image gas release in a targeted region. This review provides a summary of recent advances in therapeutic gas delivery using microbubbles and liposomes. (C) 2015 Elsevier B.V. All rights reserved.
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