期刊
JOURNAL OF CONTROLLED RELEASE
卷 220, 期 -, 页码 584-591出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2015.09.008
关键词
Electrospun fibers; Uniaxial; Coaxial; Sustained release; Drug delivery
资金
- US National Institutes of Health [AI094412, AI112002]
- Bill and Melinda Gates Foundation [1067729]
Electrospun drug-eluting fibers are emerging as a novel dosage form for multipurpose prevention against sexually transmitted infections, including HIV, and unintended pregnancy. Previous work from our lab and others show the versatility of this platform to deliver large doses of physico-chemically diverse agents. However, there is still an unmet need to develop practical fiber formulations for water-soluble small molecule drugs needed at high dosing due to intrinsic low potency or desire for sustained prevention. To date, most sustained release fibers have been restricted to the delivery of biologics or hydrophobic small molecules at low drug loading of typically <1 wt.%, which is often impractical for most clinical applications. For hydrophilic small molecule drugs, their high aqueous solubility and poor partitioning and incompatibility with insoluble polymers make long-term release even more challenging. Here we investigate several existing strategies to sustain release of hydrophilic small molecule drugs that are highly-loaded in electrospun fibers. In particular, we investigate what is known about the design constraints required to realize multi-day release from fibers fabricated from uniaxial and coaxial electrospinning. (C) 2015 Elsevier B.V. All rights reserved.
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