期刊
JOURNAL OF CONTROLLED RELEASE
卷 199, 期 -, 页码 132-144出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2014.11.017
关键词
Transungual; Nail lacquer; Nail hydration; Keratin binding; Transungual penetration enhancer; Dermatophytes; Antifungal; Amorolfine; Ciclopirox; Efinaconazole; Luliconazole; Tavaborole; Terbinafine
The human nail plate is a formidable barrier to drug permeation. Development of therapeutics for management of nail diseases thus remains a challenge. This article reviews the current knowledge and recent advances in the field of transungual drug delivery and provides guidance on development of topical/ungual therapeutics for management of nail diseases, with special emphasis on management of onychomycosis, the most common nail disease. Selection of drug candidates, drug delivery approaches, and evaluation of formulations are among the topics discussed. A comprehensive mathematical description for transungual permeation is also introduced. (C) 2014 Elsevier B.V. All rights reserved.
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