期刊
BRITISH JOURNAL OF PHARMACOLOGY
卷 162, 期 6, 页码 1225-1238出版社
WILEY
DOI: 10.1111/j.1476-5381.2010.01118.x
关键词
Sphingosine-1-phosphate; S1P; cancer; age-related macular degeneration; wet AMD; antibody therapeutics; ocular disease; choroidal neovascularization; retinal pigmented epithelial cells
资金
- National Eye Institute (NEI) [R43EYO18020]
- National Cancer Institute (NCI) [5R44CA110298]
Sphingosine-1-phosphate (S1P) is a pleiotropic bioactive lipid thought to be dysregulated in a variety of disease conditions. In this review, we discuss the roles of S1P in cancer and in wet age-related macular degeneration. We also explore potential treatment strategies for these disorders, including the utility of anti-S1P antibodies acting as molecular sponges to neutralize dysregulated S1P in relevant tissues.
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