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Ligand binding assays at equilibrium: validation and interpretation

期刊

BRITISH JOURNAL OF PHARMACOLOGY
卷 161, 期 6, 页码 1219-1237

出版社

WILEY
DOI: 10.1111/j.1476-5381.2009.00604.x

关键词

receptor; GPCR; equilibrium; kinetics; radioligand; ligand binding assay; antagonist; K-d; K-dA; competitive; depletion; allosteric; buffer; entropy; enthalpy; temperature

资金

  1. Medical Research Council, UK [U1175.03.003.00008.01]
  2. MRC [MC_U117532184] Funding Source: UKRI
  3. Medical Research Council [MC_U117532184] Funding Source: researchfish

向作者/读者索取更多资源

This article is part of a themed section on Analytical Receptor Pharmacology in Drug Discovery. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2010.161.issue-6.

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