期刊
BRITISH JOURNAL OF PHARMACOLOGY
卷 157, 期 2, 页码 195-206出版社
WILEY
DOI: 10.1111/j.1476-5381.2009.00057.x
关键词
cell-penetrating peptide; non-covalent delivery system; siRNA; nanoparticle; drug delivery; molecular mechanisms; therapeutics
资金
- Agence Nationale de Recherche [ANR-06-BLAN-0071]
- EU [QLK2-CT-2001-01451, LSHB-CT-2003-503480/TRIoH]
The recent discovery of new potent therapeutic molecules that do not reach the clinic due to poor delivery and low bioavailability have made of delivery a key stone in therapeutic development. Several technologies have been designed to improve cellular uptake of therapeutic molecules, including cell-penetrating peptides (CPPs). CPPs were first discovered based on the potency of several proteins to enter cells. Numerous CPPs have been described so far, which can be grouped into two major classes, the first requiring chemical linkage with the drug for cellular internalization and the second involving formation of stable, non-covalent complexes with drugs. Nowadays, CPPs constitute very promising tools for non-invasive cellular import of cargo and have been successfully applied for in vitro and in vivo delivery of therapeutic molecules varying from small chemical molecule, nucleic acids, proteins, peptides, liposomes and particles. This review will focus on the structure/function and cellular uptake mechanism of CPPs in the general context of drug delivery. We will also highlight the application of peptide carriers for the delivery of therapeutic molecules and provide an update of their clinical evaluation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据