期刊
BRITISH JOURNAL OF PHARMACOLOGY
卷 147, 期 -, 页码 S163-S171出版社
WILEY
DOI: 10.1038/sj.bjp.0706406
关键词
cannabis; cannabinoids; endocannabinoids; cannabinoid receptor agonists; cannabinoid receptor antagonists; anandamide; 2-arachidonoyl glycerol; autoprotection; autoimpairment
资金
- NATIONAL INSTITUTE ON DRUG ABUSE [P01DA009789] Funding Source: NIH RePORTER
- NIDA NIH HHS [DA09789, P01 DA009789] Funding Source: Medline
Research into the pharmacology of individual cannabinoids that began in the 1940s, several decades after the presence of a cannabinoid was first detected in cannabis, is concisely reviewed. Also described is how this pharmacological research led to the discovery of cannabinoid CB1 and CB2 receptors and of endogenous ligands for these receptors, to the development of CB1- and CB2-selective agonists and antagonists and to the realization that the endogenous cannabinoid system has significant roles in both health and disease, and that drugs Which mimic, augment or block the actions of endogenously released cannabinoids must have important therapeutic applications. Some goals for future research are identified.
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