期刊
BRITISH JOURNAL OF PHARMACOLOGY
卷 153, 期 -, 页码 S339-S346出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjp.0707606
关键词
orphan GPCR; reverse pharmacology; neuropeptides; orexins; MCH; ghrelin; transmitters
资金
- NIDDK NIH HHS [DK70619, R01 DK070619, R01 DK063001, DK63001] Funding Source: Medline
- NIMH NIH HHS [MH60231, R01 MH060231] Funding Source: Medline
Orphan G protein-coupled receptors (GPCRs) are receptors lacking endogenous ligands. Found by molecular biological analyses, they became the roots of reverse pharmacology, in which receptors are attempted to be matched to potential transmitters. Later, when high-throughput screening technology was applied to reverse pharmacology, dozens of orphan GPCRs became deorphanized. Furthermore, novel neuropeptides were discovered. This review retraces the history of the orphan GPCRs and of the discoveries of their endogenous ligands, it also discusses the difficulties that the search for new ligands is presently encountering.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据