期刊
BRITISH JOURNAL OF PHARMACOLOGY
卷 153, 期 -, 页码 S298-S309出版社
WILEY
DOI: 10.1038/sj.bjp.0707508
关键词
G-protein; arrestins; G-protein-independent; GPCR; 7-TMR; heterotrimeric g-protein; G alpha
资金
- NIGMS NIH HHS [R01GM066151, R01 GM066151-04, R01 GM066151] Funding Source: Medline
G-protein-coupled receptors (GPCRs), also known as seven transmembrane receptors (7-TMRs), are the largest protein receptor superfamily in the body. These receptors and their ligands direct a diverse array of physiological responses, and hence have broad relevance to numerous diseases. As a result, they have generated considerable interest in the pharmaceutical industry as drug targets. Recently, GPCRs have been demonstrated to elicit signals through interaction with the scaffolding proteins, beta-arrestins-1 and 2, independent of heterotrimeric G-protein coupling. This review discusses several known G-protein-independent, beta-arrestin-dependent pathways and their potential physiological and pharmacological significance. The emergence of G-protein-independent signalling changes the way in which GPCR signalling is evaluated, from a cell biological to a pharmaceutical perspective and raises the possibility for the development of pathway specific therapeutics.
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