期刊
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
卷 52, 期 9, 页码 854-859出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.bjoms.2014.07.256
关键词
Bisphosphonate; Osteonecrosis of the jaw; Platelet-rich fibrin; Growth factor; Platelet concentrate
资金
- Ewha Womans University, Seoul, Korea
Our aim was to assess the feasibility of using leucocyte-rich and platelet-rich fibrin (L-PRF) for the treatment of bisphosphonate-related osteonecrosis of the jaw (BRONJ) in a single group study. After treatment with L-PRF, the response of each patient was recorded 1 month and 4 months postoperatively. Further assessments were made of the site, stage, concentration of c-terminal crosslinked telopepide of type 1 collagen, and actinomycosis. Among the total of 34 patients, 26 (77%) showed complete resolution, 6 (18%) had delayed resolution, and 2 (6%) showed no resolution. There was a significant association between the response to treatment and the stage of BRONJ (p = 0.002) but no other significant associations were detected. This study has shown that it is feasible to use L-PRF for the treatment of BRONJ, but the effectiveness cannot be judged with this study design. Randomised prospective trials are needed to confirm this. (C) 2014 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
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