期刊
BRITISH JOURNAL OF NUTRITION
卷 120, 期 5, 页码 557-566出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0007114518001708
关键词
Pregnancy; Traditional dietary patterns; Antiretroviral treatment; Neonatal adiposity; South AM
资金
- DST-NRF Centre of Excellence (CoE) in Human Development at the University of the Witwatersrand, Johannesburg, in the Republic of South Africa
- UK MRC/DfID African Research Leader Scheme
- South African Medical Research Council
- ESRC [ES/N013891/1] Funding Source: UKRI
- MRC [MC_UU_12015/2] Funding Source: UKRI
This study examines the associations between maternal Traditional dietary pattern adherence and HIV/treatment with neonatal size and adiposity in urban, black South Africans, as well as how specific maternal factors - that is BMI and gestational weight gain (GWG) - may influence these associations. Multiple linear regression models were used to examine associations among maternal Traditional diet pattern adherence (pattern score), HIV/treatment status (three groups: HIV negative, HIV positive (antenatal antiretroviral treatment (ART) initiation), HIV positive (pm-pregnancy ART initiation)), BMI and GWG (kg/week), and newborn (1) weight:length ratio (WLR. kg/m) in 393 mother-neonate pairs, and (2) Peapod estimated fat mass index (EMI, kg/m(3)) in a 171-pair subsample. In fully adjusted models, maternal obesity and GWG were associated with 0.25 kg/m (P=0.008) and 0.48 kg/m (P=0.002) higher newborn WLR, whereas Traditional diet pattern score was associated with lower newborn WLR (-0.04 kg/m per +1 SD; P=0.033). In addition, Traditional diet pattern score was associated with 0.13 kg/m(3) (P=0.027) and 0.32 kg/m(3) (P= 0.005) lower FMI in the total sample and in newborns of normal-weight women, respectively. HIV-positive (pre-pregnancy ART) v. HIV-negative (ref) status was associated with 141 kg/m(3) (P= 0.002) higher newborn FMI. Promotion of a Traditional dietary pattern, alongside a healthy maternal pre-conception weight, in South African women may reduce newborn adiposity and metabolic risk profiles. In HIV-positive women, targeted monitoring and management strategies are necessary to limit treatment-associated effects on in utero fat deposition.
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