期刊
BRITISH JOURNAL OF NUTRITION
卷 113, 期 2, 页码 292-298出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0007114514003626
关键词
Diet; Inflammation; Pancreatic cancer; Case-control studies; Italy; Risk
资金
- Italian Foundation for Cancer Research (FIRC)
- IRCCS Centro di Riferimento Oncologico, Aviano (Ricerca Corrente), Italy
- Cancer Training Branch of the National Cancer Institute [K05 CA136975]
- Associazione Italiana per la Ricerca sul Cancro Funding Source: Custom
Previous studies have shown that various dietary components may be implicated in the aetiology of pancreatic cancer. However, the possible relationship between diet-related inflammation and the risk of pancreatic cancer has not yet been investigated. We examined the ability of a newly developed literature-derived dietary inflammatory index (DII) to predict the risk of pancreatic cancer in a case-control study conducted in Italy between 1991 and 2008. This included 326 incident cases and 652 controls admitted to the major teaching and general hospitals for non-neoplastic diseases, frequency-matched to cases by study centre, sex and age. The DII was computed based on dietary intake assessed using a validated and reproducible seventy-eight-item FFQ. Logistic regression models were used to estimate multivariable OR adjusted for age, sex, study centre, education, BMI, smoking status, alcohol drinking and history of diabetes. Energy adjustment was performed using the residual method. Subjects with higher DII scores (i.e. representing a more pro-inflammatory diet) had a higher risk of pancreatic cancer, with the DII being used as both a continuous variable (ORcontinuous 1.24, 95% CI 1.11, 1.38) and a categorical variable (i.e. compared with the subjects in the lowest quintile of the DII, those in the second, third, fourth and fifth quintiles had, respectively, ORquintile2 v.1 1.70, 95% CI 1.02, 2.80; ORquintile3 v.1 1.91, 95% CI 1.16, 3.16; ORquintile4 v.1 1.98, 95% CI 1.20, 3.27; ORquintile5 v. 1 2.48, 95% CI 1.50, 4.10; P-trend = 0.0015). These data suggest that a pro-inflammatory diet increases the risk of pancreatic cancer.
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