期刊
ANALYTICAL CHEMISTRY
卷 87, 期 24, 页码 12206-12214出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.5b03084
关键词
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资金
- Guangdong Provincial Department of Science and Technology of China [2015A010105016]
- Guangdong Provincial Natural Science Foundation of China [2015A030313284]
- National Natural Science Foundation of China [21102070, 21201025]
- Program for Pearl River New Stars of Science and Technology in Guangzhou [2011J2200071]
- Natural Science Fund of Jiangsu Province of China [11KJB150001]
- Qin-Lan Program of Jiangsu Province
- Southern Medical University
We herein report a water-stable three-dimensional Cu-based metal-organic framework (MOF) 1 supported by a tritopic quaternized carboxylate and 4,4'-dipyridyl sulfide as an ancillary ligand. This MOF exhibits unique pore shapes with aromatic rings, positively charged pyridinium and unsaturated Cu(II) cation centers, free carboxylates, tessellating H2O, and coordinating SO42- on the pore surface. Compound 1 can interact with two carboxyfluorescein (FAM)-labeled single-stranded DNA sequences (probe ss-DNA, delineated as P-DNA) through electrostatic, pi-stacking, and/or hydrogen-bonding interactions to form two P-DNA@1 systems, and thus quench the fluorescence of FAM via a photoinduced electron-transfer process. These P-DNA@1 systems can be used as effective fluorescent sensors for human immunodeficiency virus 1 double-stranded DNA and Sudan virus RNA sequences, respectively, with detection limits of 196 and 73 pM, respectively.
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