期刊
BRITISH JOURNAL OF NUTRITION
卷 109, 期 11, 页码 1980-1989出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0007114512004205
关键词
Gluco-oligosaccharides; Prebiotics; Obese subjects
资金
- Department of Food and Nutritional Sciences, University of Reading
- Sarawak Foundation
- Universiti Putra Malaysia of the Malaysian government
The fermentation selectivity of a commercial source of alpha-gluco-oligosaccharides (BioEcolians; Solabia) was investigated in vitro. Fermentation by faecal bacteria from four lean and four obese healthy adults was determined in anaerobic, pH-controlled faecal batch cultures. Inulin was used as a positive prebiotic control. Samples were obtained at 0, 10, 24 and 36 h for bacterial enumeration by fluorescent in situ hybridisation and SCFA analyses. Gas production during fermentation was investigated in non-pH-controlled batch cultures. alpha-Gluco-oligosaccharides significantly increased the Bifidobacterium sp. population compared with the control. Other bacterial groups enumerated were unaffected with the exception of an increase in the Bacteroides-Prevotella group and a decrease in Faecalibacterium prausnitzii on both alpha-gluco-oligosaccharides and inulin compared with baseline. An increase in acetate and propionate was seen on both substrates. The fermentation of alpha-gluco-oligosaccharides produced less total gas at a more gradual rate of production than inulin. Generally, substrates fermented with the obese microbiota produced similar results to the lean fermentation regarding bacteriology and metabolic activity. No significant difference at baseline (0 h) was detected between the lean and obese individuals in any of the faecal bacterial groups studied.
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