期刊
BRITISH JOURNAL OF NUTRITION
卷 108, 期 8, 页码 1443-1454出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0007114511006878
关键词
n-3 Long-chain PUFA; Infant supplementation; Neurodevelopment; Language
资金
- National Health and Medical Research Council (NHMRC) of Australia [458502]
- NHMRC
- Women & Infants' Research Foundation
- Asthma Foundation of Australia
n-3 Long-chain PUFA (LC-PUFA) intake during infancy is important for neurodevelopment; however, previous studies of n-3 LC-PUFA supplementation have been inconclusive possibly due to an insufficient dose and limited methods of assessment. The present study aimed to evaluate the effects of direct supplementation with high-dose fish oil (FO) on infant neurodevelopmental outcomes and language. In the present randomised, double-blind, placebo-controlled trial, 420 healthy term infants were assigned to receive a DHA-enriched FO supplement (containing at least 250 mg DHA/d and 60 mg EPA/d) or a placebo (olive oil) from birth to 6 months. Assessment occurred at 18 months via the Bayley Scales of Infant and Toddler Development (3rd edition; BSID-III) and the Child Behavior Checklist. Language assessment occurred at 12 and 18 months via the Macarthur-Bates Communicative Development Inventory. The FO group had significantly higher erythrocyte DHA (P=0.03) and plasma phospholipid DHA (P=0.01) levels at 6 months of age relative to placebo. In a small subset analysis (about 40% of the total population), children in the FO group had significantly higher percentile ranks of both later developing gestures at 12 and 18 months (P=0.007; P=0.002, respectively) and the total number of gestures (P=0.023; P=0.006, respectively). There was no significant difference between the groups in the standard or composite scores of the BSID-III. The results suggest that improved postnatal n-3 LC-PUFA intake in the first 6 months of life using high-dose infant FO supplementation was not beneficial to global infant neurodevelopment. However, some indication of benefits to early communicative development was observed.
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