期刊
BRITISH JOURNAL OF NUTRITION
卷 106, 期 3, 页码 425-431出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0007114511000171
关键词
Diet; Cardiovascular risk; EPA; DHA; PUFA; SFA
资金
- Spanish Health Ministry [FIS PI06/0365]
- Centro Nacional de Investigaciones Cardiovasculares
- Fundacio Privada Catalana de Nutricio i Lipids, Barcelona, Spain
- [FIS CD07/0083]
The omega-3 index, defined as the sum of EPA and DHA in erythrocyte membranes expressed as a percentage of total fatty acids, has been proposed as both a risk marker and risk factor for CHD death. A major determinant of the omega-3 index is EPA + DHA intake, but the impact of other dietary fatty acids has not been investigated. In a cross-sectional study on 198 subjects (102 men and 96 women, mean age 66 years) at high cardiovascular risk living in Spain, the country with low rates of cardiac death despite a high prevalence of cardiovascular risk factors, dietary data were acquired from FFQ and blood cell membrane fatty acid composition was measured by GC. The average consumption of EPA + DHA was 0.9 g/d and the mean omega-3 index was 7.1%. In multivariate models, EPA + DHA intake was the main predictor of the omega-3 index but explained only 12% of its variability (P<0.001). No associations with other dietary fatty acids were observed, Although the single most influential determinant of the omega-3 index measured here was the intake of EPA + DHA, it explained little of the former's variability; hence, the effects of other factors (genetic, dietary and lifestyle) remain to be determined. Nevertheless, the high omega-3 index could at least partially explain the paradox of low rates of fatal CHD in Spain despite a high background prevalence of cardiovascular risk factors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据