期刊
BRITISH JOURNAL OF NUTRITION
卷 105, 期 2, 页码 167-170出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0007114510004356
关键词
Curcumin; Paraoxonase; Hepatocytes; Mice; Atherosclerosis
资金
- German Federal Ministry of Education and Research [0315679]
Paraoxonase 1 (PON1) is an enzyme that is mainly synthesised in the liver and protects LDL from oxidation, thereby exhibiting antiatherogenic properties. Using a luciferase reporter gene assay, we tested curcumin for its ability to induce PON1 in Huh7 hepatocytes in culture. Curcumin (>= 10 mu mol/l) dose-dependently induced PON1 transactivation in Huh7 cells. However, dietary supplementation of female B6C3F1 mice with curcumin (500 mg/kg diet) for 2 weeks did not increase the hepatic PON1 mRNA and protein levels. No curcumin was detectable in the plasma of the 12 h fasted mice. In conclusion, curcumin may be a potent PON1 inducer in cultured cells in vitro, but not in the liver of curcumin-fed mice because of its low concentrations in vivo.
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