期刊
BRITISH JOURNAL OF NUTRITION
卷 103, 期 7, 页码 1070-1078出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0007114509992807
关键词
Intestinal microbiota; Inflammation; Overweight
资金
- Danisco A/S
A cross-sectional study was carried out in order to compare intestinal microbiological and immunological biomarkers with blood glucose and lipids, satiety-related hormones and inflammatory biomarkers characterising differences between obese and normal weight subjects. Faecal and blood samples were obtained from twenty obese subjects with an average BMI of 32.9 kg/m(2) and twenty normal weight subjects with an average BMI of 23.3 kg/m(2). Blood insulin, TAG and leptin were significantly elevated, whereas concentrations of HDL and ghrelin were significantly decreased in the obese subjects. Inflammatory status in the obese subjects was characterised by a trend for elevated blood C-reactive protein (CRP; P=0.06) and IL-6 (P=0.02). The faecal microbial composition differed between the groups; less sulphate-reducing bacteria (P=0.05) and a trend for less Bacteroides (P=0.07) were measured for overweight subjects. Furthermore, an inverse correlation was demonstrated between faecal Bacteroides levels and waist circumference (P=0.05). The faecal microbial metabolites differed between the groups; increased concentrations of branched-chain fatty acids, phenolics, valeric acid, di- and hydroxy acids were described in the obese subjects. No differences between the measured intestinal inflammatory biomarkers were detected. However, systemic inflammation (CRP and IL-6) was correlated with the faecal concentrations of phenolics and lactic acid (P<0.05 and 0.05, and P<0.01 and 0.05, respectively). In summary, weight-related differences were observed both in the intestinal microbial composition and its activity. The role of intestinal signals, such as phenolics and lactic acid in the development of weight-related problems, needs to be studied further.
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