期刊
ANALYTICAL CHEMISTRY
卷 88, 期 1, 页码 1052-1057出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.5b04248
关键词
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资金
- National Basic Research Program [2013CB834703, 2013CB834505, 2011CBA00905, 2009CB930802]
- National Natural Science Foundation of China [21233011, 91123033, 21273252, 21205122, 21261160488, 21072196]
Hydrogen sulfide (H2S) is a multifunctional signaling molecule that participates in many important biological processes. Herein, by functionalizing triarylboron with cyclen and diphenylamine, we synthesized TAB-1, TAB-2, and TAB-3 for H2S recongnization by rational design of molecular structures. Among them, aqueous soluble TAB-2 possesses excellent properties, including large two-photon action cross section, membrane permeability and can effectively complex with Cu2+ The complex of TAB-2-Cu2+ can selectively detect H2S with an instant response and mitochondria targeted. Moreover, the H2S-induced finite aggregation of indicators enhances their photostability and causes variation of the fluorescence lifetime. TAB-2-Cu2+ has also been successfully applied for the mitochondria H2S imaging in NIH/3T3 fibroblast cells by TPM and FLIM.
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