期刊
BRITISH JOURNAL OF NUTRITION
卷 100, 期 6, 页码 1152-1157出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0007114508992576
关键词
Membrane rafts; n-3 Fatty acids; Conjugated fatty acids; Microdomains
资金
- National Institutes of Health [CA59034, CA 129444, DK071707, P30ES09106]
- US Department of Agriculture [2005-34402-16401]
- Designing Foods for Health
- American Institute for Cancer Research
The plasma membranes of all eukaryotic cells contain heterogeneous self-organising intrinsically unstable liquid ordered domains or lipid assemblies in which key signal transduction proteins are localised. These assemblies are classified as 'lipid rafts' (10-200 nm), which are composed mostly of cholesterol and sphingolipid microdomains and therefore do not integrate well into the fluid phospholipid bilayers. In addition, caveolae represent a subtype of lipid raft macrodomain that form flask-shaped membrane invaginations containing structural proteins, i.e. caveolins. With respect to the diverse biological effects of long-chain PUFA, increasing evidence suggests that n-3 PUFA and perhaps conjugated fatty acids uniquely alter the basic properties of cell membranes. Because of its polyunsaturation, DHA and possibly conjugated linoleic acid are sterically incompatible with sphingolipid and cholesterol and, therefore, appear to alter lipid raft behaviour and protein function. The present review examines the evidence indicating that dietary sources of n-3 PUFA can profoundly alter the biochemical make tip of lipid rafts/caveolae microdomains, thereby influencing cell signalling. protein trafficking and cell cytokinetics.
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