期刊
BRITISH JOURNAL OF NUTRITION
卷 100, 期 4, 页码 707-710出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S000711450894215X
关键词
Lupinus albus; Protein isolates; Cholesterol; Atherosclerosis; Rabbits
资金
- European Commission
- Fifth Framework Programme
- Quality of Life and Management of Living Resources Programme
- Healthy Profood [QLRT 2001-2235]
The biological activities of a protein isolate from lupin (Lupinus albus) were studied in a rabbit model of atherosclerosis. Focal plaque development was induced at both common carotid arteries by perivascular injury. After surgery. animals were fed three different diets for 90d, all with 1% cholesterol. 15 % SFA and 20 % protein: the protein source was casein (CAS), lupin proteins (LUP) or 50 % CAS + 50 % LUP (CAS + LUP). Lower cholesterolaemia was detected in the LUP v. the CAS group at 60 and 90 d of treatment (- 40.3 and - 33-5 %, respectively; P<0-05). Cryosection analyses of the carotids indicated a significant reduction in focal lesion progression in the LUP v. the CAS group (-37.4%; P<0.05). In summary. in a rabbit model of atherosclerosis. a protein isolate from L. albus reduced cholesterolaemia and exerted a remarkable protective activity against atherosclerosis progression.
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