期刊
BRITISH JOURNAL OF NUTRITION
卷 101, 期 9, 页码 1360-1368出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0007114508079592
关键词
Fat; Modified sham feeding; Satiety; Energy expenditure; Substrate oxidation; H-2-labelled palmitic acid
资金
- The Netherlands and by the European project DiOGenes [FP6-513946]
Previously, we have shown that satiety and metabolites increased after high-fat modified sham feeding (MSF). We assessed possible metabolic effects due to oral stimulation with a high-fat sham-fed 'meal', in comparison with a high-fat fed meal and with water, in the postprandial state. Fourteen healthy women (aged 18-40 years; BMI 22.5 (SD 3) kg/m(3)) were fed in energy balance during 4d with a 50% enegy as carbohydrate, 15% energy as protein and 35% energy as fat menu. On day 4, subjects were given one out of three test lunches, 5 h after a high-fat breakfast, in random order: a high-fat MSF lunch, water (W) or the same lunch to be eaten (E), during their 36 h stay in the respiration chamber, where substrate oxidation, 24 h energy expenditure (EE) and appetite profile were measured. Oral fat stimulation by MSF increased EE (W 6.3 (SD 0.8) v. MSF 6.9 (SD 1.0) kJ/min and E 6.8 (SD 0.7) kJ/min; P<0.04) for 1 h, increased plasma insulin concentrations (t = 15; W 10.0 (SD 3.4) v. MSF 13.2 (SD 4.0) v. E 22.3 (SD 3.3) units/l; P<0.0001), attenuated changes in plasma NEFA concentrations (t = 15, W 432 (SD 108) v. MSF 418 (SD 146) v. E 282 (so 72) mu mol/l; P<0.0001), plasma TAG concentrations (t = 60; W 1092 (SD 548) v. MSF 1116 (SD 493) mu mol/l and E 1350 (SD 352) mu mol/l; P<0.02) and plasma glycerol concentrations (t = 15, W 87 (SD 29) v. MSF 74 (So 34) mu mol/l and E 67 (SD 18) mu mol/l; P<0.03). Over a longer period of time, MSF had no effects on substrate oxidation, diet-induced thermogenesis or total EE. In addition to the previously observed metabolic effects of oral stimulation with fat, EE is stimulated up to 1 h after the MSF meal.
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