An improved synthesis of Telmisartan: an antihypertensive drug

An improved, convergent and industrially useful process suitable for large-scale production of Telmisartan has been described. The key steps are Suzuki coupling for the preparation of key intermediate 2-[4'-(chloromethyl)biphenyl-2-yl]-4,4-dimethyl-4,5-dihydro-1,3-oxazole of Telmisartan, N-alkylation and oxazoline hydrolysis.