期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 168, 期 4, 页码 553-556出版社
WILEY
DOI: 10.1111/bjh.13179
关键词
sickle cell disease; silent cerebral infarcts; neurocognitive functioning
类别
Sickle cell disease can be complicated by cerebral white matter hyperintensities (WMHs), which are associated with diminished neurocognitive functioning. The influence of the total volume of WMHs on the degree of neurocognitive dysfunction has not yet been characterized. In our study of 38 patients (mean age 125years) we demonstrated that a higher volume of WMHs was associated with lower full-scale intelligence quotient (IQ), verbal IQ, Processing Speed Index and more fatigue. Our results suggest that volume of WMHs is an additional parameter to take into account when planning individual diagnostic and treatment options.
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