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GATA1s induces hyperproliferation of eosinophil precursors in Down syndrome transient leukemia
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Domains of genome-wide gene expression dysregulation in Down's syndrome
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Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation
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Naturally occurring oncogenic GATA1 mutants with internal deletions in transient abnormal myelopoiesis in Down syndrome
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BLOOD (2013)
Perturbation of fetal hematopoiesis in a mouse model of Down syndrome's transient myeloproliferative disorder
Yehudit Birger et al.
BLOOD (2013)
Exome sequencing identifies putative drivers of progression of transient myeloproliferative disorder to AMKL in infants with Down syndrome
Sergey I. Nikolaev et al.
BLOOD (2013)
Development of acute megakaryoblastic leukemia in Down syndrome is associated with sequential epigenetic changes
Sebastien Malinge et al.
BLOOD (2013)
GATA1-mutant clones are frequent and often unsuspected in babies with Down syndrome: identification of a population at risk of leukemia
Irene Roberts et al.
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Prognostic features in acute megakaryoblastic leukemia in children without Down syndrome: a report from the AML02 multicenter trial and the Children's Oncology Group Study POG 9421
M. M. O'Brien et al.
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Translating dosage compensation to trisomy 21
Jun Jiang et al.
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The landscape of somatic mutations in Down syndrome-related myeloid disorders
Kenichi Yoshida et al.
NATURE GENETICS (2013)
Massively Parallel Sequencing Reveals the Complex Structure of an Irradiated Human Chromosome on a Mouse Background in the Tc1 Model of Down Syndrome
Susan M. Gribble et al.
PLOS ONE (2013)
Clinical characteristics and outcome of refractory/relapsed myeloid leukemia in children with Down syndrome
Takashi Taga et al.
BLOOD (2012)
Mutational Processes Molding the Genomes of 21 Breast Cancers
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Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome
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JOURNAL OF CLINICAL INVESTIGATION (2012)
Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia
Vijay G. Sankaran et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21
Anindita Roy et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Trisomy 21-associated defects in human primitive hematopoiesis revealed through induced pluripotent stem cells
Stella T. Chou et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Altered hematopoiesis in trisomy 21 as revealed through in vitro differentiation of isogenic human pluripotent cells
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Tumorigenesis in Down's syndrome: big lessons from a small chromosome
Dean Nizetic et al.
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RUNX1 mutations are frequent in de novo AML with noncomplex karyotype and confer an unfavorable prognosis
Susanne Schnittger et al.
BLOOD (2011)
GABP controls a critical transcription regulatory module that is essential for maintenance and differentiation of hematopoietic stem/progenitor cells
Shuyang Yu et al.
BLOOD (2011)
Analysis of GATA1 mutations in Down syndrome transient myeloproliferative disorder and myeloid leukemia
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BLOOD (2011)
Natural history of transient myeloproliferative disorder clinically diagnosed in Down syndrome neonates: a report from the Children's Oncology Group Study A2971
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BLOOD (2011)
Gain-of-function mutations in interleukin-7 receptor-α (IL7R) in childhood acute lymphoblastic leukemias
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JOURNAL OF EXPERIMENTAL MEDICINE (2011)
Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome
Ashley P. Ng et al.
BLOOD (2010)
Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group
Libi Hertzberg et al.
BLOOD (2010)
Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome
Kate A. Alford et al.
BLOOD (2010)
Peripheral blood cell counts in infants with Down's syndrome
S. M. Kivivuori et al.
CLINICAL GENETICS (2010)
Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis
Jan-Henning Klusmann et al.
GENES & DEVELOPMENT (2010)
miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia
Jan-Henning Klusmann et al.
GENES & DEVELOPMENT (2010)
Hsa-mir-125b-2 is highly expressed in childhood ETV6/RUNX1 (TEL/AML1) leukemias and confers survival advantage to growth inhibitory signals independent of p53
N. Gefen et al.
LEUKEMIA (2010)
Down Syndrome B-Lymphocyte Subpopulations, Intrinsic Defect or Decreased T-Lymphocyte Help
Ruud H. J. Verstegen et al.
PEDIATRIC RESEARCH (2010)
Fetal liver hepatic progenitors are supportive stromal cells for hematopoietic stem cells
Song Chou et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Hematopoietic defects in the Ts1Cje mouse model of Down syndrome
Catherine L. Carmichael et al.
BLOOD (2009)
Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome
Sebastien Malinge et al.
BLOOD (2009)
RUNX1 regulates phosphoinositide 3-kinase/AKT pathway: role in chemotherapy sensitivity in acute megakaryocytic leukemia
Holly Edwards et al.
BLOOD (2009)
Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia
Lisa J. Russell et al.
BLOOD (2009)
The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes
James W. Vardiman et al.
BLOOD (2009)
Acute megakaryoblastic leukaemia (AMKL) and transient myeloproliferative disorder (TMD) in Down syndrome: a multi-step model of myeloid leukaemogenesis
Anindita Roy et al.
BRITISH JOURNAL OF HAEMATOLOGY (2009)
ERG Is a Megakaryocytic Oncogene
Samira Salek-Ardakani et al.
CANCER RESEARCH (2009)
Intrinsic defect of the immune system in children with Down syndrome: a review
M. A. A. Kusters et al.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2009)
Constitutional aneuploidy and cancer predisposition†
Ithamar Ganmore et al.
HUMAN MOLECULAR GENETICS (2009)
Hematological abnormalities in adult patients with Down's syndrome
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IRISH JOURNAL OF MEDICAL SCIENCE (2009)
Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia
Charles G. Mullighan et al.
NATURE GENETICS (2009)
The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies
Jan O. Korbel et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome
Gina Kirsammer et al.
BLOOD (2008)
Abnormalities in the myeloid progenitor compartment in Down syndrome fetal liver precede acquisition of GATA1 mutations
Oliver Tunstall-Pedoe et al.
BLOOD (2008)
Trisomy 21 enhances human fetal erythro-megakaryocytic development
Stella T. Chou et al.
BLOOD (2008)
Treatment and prognostic impact of transient leukemia in neonates with Down syndrome
Jan-Henning Klusmann et al.
BLOOD (2008)
The role of parathyroid hormone and insulin-like growth factors in hematopoietic niches: Physiology and pharmacology
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MOLECULAR AND CELLULAR ENDOCRINOLOGY (2008)
Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome
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LANCET (2008)
Acute Leukemias in children with Down syndrome
Michel C. Zwaan et al.
PEDIATRIC CLINICS OF NORTH AMERICA (2008)
Myeloid leukemia in children 4 years or older with Down syndrome often lacks GATA1 mutation and cytogenetics and risk of relapse are more akin to sporadic AML
H. Hasle et al.
LEUKEMIA (2008)
Cytogenetic features of acute lymphoblastic and myeloid leukemias in pediatric patients with Down syndrome:: an iBFM-SG study
Erik Forestier et al.
BLOOD (2008)
Gene expression profiling in the adult Down syndrome brain
H. E. Lockstone et al.
GENOMICS (2007)
Incidence and clinical implications of GATA1mutations in newborns with Down syndrome
Sharon R. Pine et al.
BLOOD (2007)
Classification of human chromosome 21 gene-expression variations in down syndrome:: Impact on disease phenotypes
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AMERICAN JOURNAL OF HUMAN GENETICS (2007)
Altered expression of mitochondrial and extracellular matrix genes in the heart of human fetuses with chromosome 21 trisomy
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BMC GENOMICS (2007)
Natural gene-expression variation in Down syndrome modulates the outcome of gene-dosage imbalance
Paola Prandini et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2007)
Severe TMD/AMKL with GATA1 mutation in a stillborn fetus with Down syndrome
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NATURE CLINICAL PRACTICE ONCOLOGY (2007)
Hematological abnormalities during the first week of life among neonates with Down syndrome: Data from a multihospital healthcare system
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AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2007)
Prediction of chromosomal aneuploidy from gene expression data
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GENES CHROMOSOMES & CANCER (2007)
Islet autointmunity in children with Down's syndrome
Kathleen M. Gillespie et al.
DIABETES (2006)
An inherited mutation leading to production of only the short isoform of GATA-1 is associated with impaired erythropoiesis
Luciana M. Hollanda et al.
NATURE GENETICS (2006)
A prospective study of the natural history of transient leukemia (TL) in neonates with Down syndrome (DS): Children's Oncology Group (COG) study POG-9481
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BLOOD (2006)
MicroRNA fingerprints during human megakaryocytopoiesis
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling
JP Bourquin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Physical association of the patient-specific GATA1 mutants with RUNX1 in acute megakaryoblastic leukemia accompanying Down syndrome
G. Xu et al.
LEUKEMIA (2006)
Clinical characteristics and outcome of children with Down syndrome and acute lymphoblastic leukemia: a Children's Cancer Group study
JA Whitlock et al.
BLOOD (2005)
Risk of death for children with Down syndrome and sepsis
MM Garrison et al.
JOURNAL OF PEDIATRICS (2005)
Intrinsic abnormalities of lymphocyte counts in children with Down syndrome
YCM De Hingh et al.
JOURNAL OF PEDIATRICS (2005)
Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1
Z Li et al.
NATURE GENETICS (2005)
Immunophenotype of Down syndrome acute myeloid leukemia and transient myeloproliferative disease differs significantly from other diseases with morphologically identical or similar blasts
C Langebrake et al.
KLINISCHE PADIATRIE (2005)
GATA1, cytidine deaminase, and the high cure rate of Down syndrome children with acute megakaryocytic leukemia
YB Ge et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2005)
The cerebellar transcriptome during postnatal development of the Ts1Cje mouse, a segmental trisomy model for Down syndrome
L Dauphinot et al.
HUMAN MOLECULAR GENETICS (2005)
Chromosome copy number and leukemia - Lessons from Down's syndrome
S Izraeli
HEMATOLOGY (2005)
Insulin-like growth factor 2 expressed in a novel fetal liver cell population is a growth factor for hematopoietic stem cells
CC Zhang et al.
BLOOD (2004)
The role of cytidine deaminase and GATA1 mutations in the increased cytosine arabinoside sensitivity of Down syndrome myeloblasts and leukemia cell lines
YB Ge et al.
CANCER RESEARCH (2004)
Prenatal origin of GATA1 mutations may be an initiating step in the development of megakaryocytic leukemia in Down syndrome
JW Taub et al.
BLOOD (2004)
Frequent mutations in the GATA-1 gene in the transient myeloproliferative disorder of Down syndrome
G Xu et al.
BLOOD (2003)
Mutations in exon 2 of GATA1 are early events in megakaryocytic malignancies associated with trisomy 21
L Rainis et al.
BLOOD (2003)
GATA1 mutations in transient leukemia and acute megakaryoblastic leukemia of Down syndrome
JK Hitzler et al.
BLOOD (2003)
RUNX1 and GATA-1 coexpression and cooperation in megakaryocytic differentiation
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BLOOD (2003)
Transient leukaemia - A benign form of leukaemia in newborn infants with trisomy 21
A Zipursky
BRITISH JOURNAL OF HAEMATOLOGY (2003)
A pediatric approach to the WHO classification of myelodysplastic and myeloproliferative diseases
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LEUKEMIA (2003)
Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome
J Wechsler et al.
NATURE GENETICS (2002)
Lack of age-associated LFA-1 up-regulation and impaired ICAM-1 binding in lymphocytes from patients with Down syndrome
SJ Lin et al.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2001)
Risks of leukaemia and solid tumours in individuals with Down's syndrome
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LANCET (2000)
Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1
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NATURE GENETICS (2000)
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