相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia
Erika K. Keeton et al.
BLOOD (2014)
The PIM Family of Serine/Threonine Kinases in Cancer
Maja Narlik-Grassow et al.
MEDICINAL RESEARCH REVIEWS (2014)
Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia
Liat Goldberg et al.
BLOOD (2013)
Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation
Jing Lu et al.
BLOOD (2013)
Tumour heterogeneity and cancer cell plasticity
Corbin E. Meacham et al.
NATURE (2013)
Delving deeper: MCL-1's contributions to normal and cancer biology
Rhonda M. Perciavalle et al.
TRENDS IN CELL BIOLOGY (2013)
Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases
Les A. Dakin et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
The FLT3 and Pim kinases inhibitor SGI-1776 preferentially target FLT3-ITD AML cells
Marie-Anne Hospital et al.
BLOOD (2012)
mTOR Signaling in Growth Control and Disease
Mathieu Laplante et al.
CELL (2012)
Selectively targeting Mcl-1 for the treatment of acute myelogenous leukemia and solid tumors
Gregory J. Gores et al.
GENES & DEVELOPMENT (2012)
Potential Use of Selective and Nonselective Pim Kinase Inhibitors for Cancer Therapy
Denis Drygin et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Preclinical Pharmacology of AZD5363, an Inhibitor of AKT: Pharmacodynamics, Antitumor Activity, and Correlation of Monotherapy Activity with Genetic Background
Barry R. Davies et al.
MOLECULAR CANCER THERAPEUTICS (2012)
Optimal induction of myeloma cell death requires dual blockade of phosphoinositide 3-kinase and mTOR signalling and is determined by translocation subtype
C. Stengel et al.
LEUKEMIA (2012)
Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia
Lisa S. Chen et al.
BLOOD (2011)
Coexistence of LMPP-like and GMP-like Leukemia Stem Cells in Acute Myeloid Leukemia
Nicolas Goardon et al.
CANCER CELL (2011)
For better or for worse: the role of Pim oncogenes in tumorigenesis
Martijn C. Nawijn et al.
NATURE REVIEWS CANCER (2011)
Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method
Ting-Chao Chou
CANCER RESEARCH (2010)
Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia
Zhifu Xiang et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
PIM1 protein kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells
Fengxue Zhang et al.
CANCER BIOLOGY & THERAPY (2009)
Targeting the phosphoinositide 3-kinase pathway in cancer
Pixu Liu et al.
NATURE REVIEWS DRUG DISCOVERY (2009)
Pim-1 plays a pivotal role in hypoxia-induced chemoresistance
J. Chen et al.
ONCOGENE (2009)
Hypoxia-inducible proto-oncogene Pim-1 is a prognostic marker in pancreatic ductal adenocarcinoma
Carolin Reiser-Erkan et al.
CANCER BIOLOGY & THERAPY (2008)
Activating alleles of JAK3 in acute megakaryoblastic leukemia
Denise K. Walters et al.
CANCER CELL (2006)
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders
H Quentmeier et al.
LEUKEMIA (2006)
Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival
PS Hammerman et al.
BLOOD (2005)
Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival
KT Kim et al.
BLOOD (2005)
Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias
S Zhao et al.
LEUKEMIA (2004)
Pim-1 kinase promotes inactivation of the pro-apoptotic bad protein by phosphorylating it on the Ser112 gatekeeper site
TLT Aho et al.
FEBS LETTERS (2004)
The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death
B Yan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations
M Mizuki et al.
BLOOD (2003)
Modeling pO2 distributions in the bone marrow hematopoietic compartment.: I.: Krogh's model
DC Chow et al.
BIOPHYSICAL JOURNAL (2001)