期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 167, 期 2, 页码 238-242出版社
WILEY-BLACKWELL
DOI: 10.1111/bjh.12997
关键词
nodular lymphocyte-predominant Hodgkin lymphoma; histopathological feature; prognostic impact
类别
资金
- Deutsche Forschungsgemeinschaft [HA 6145/1-1]
Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare lymphoma entity. We performed a matched-pair analysis to evaluate the prognostic impact of several histopathological features in this distinct Hodgkin lymphoma subtype. Lymph node samples of NLPHL patients were tested for CD15, IgD, phosphorylated STAT6, ICOS and Epstein-Barr virus status of the malignant lymphocyte-predominant cells as well as epithelioid cell clusters and activated T cells in the microenvironment. None of these features was associated with a particular clinical outcome. However, patients presenting with epithelioid cell clusters showed a non-significant trend towards a lower relapse rate, justifying further evaluation of this marker.
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