期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 166, 期 3, 页码 382-389出版社
WILEY
DOI: 10.1111/bjh.12906
关键词
lymphoma; chemotherapeutic approaches; diffuse large B cell lymphoma; radioimmunotherapy; pharmacotherapeutics
类别
资金
- University of Rochester SPORE in lymphoma [CA 130805]
- National Cancer Institute, DHHS, PHS [CA32102, CA38926, CA11083, CA20319, CA35090, CA13612, CA46368, CA27057, CA35128, CA35119, CA46282, CA45450, CA12644, CA04919, CA073590]
- GlaxoSmithKline
Radiolabelled antiCD-20 antibodies have demonstrated single agent activity in relapsed diffuse large B-cell lymphoma (DLBCL). The S0433 clinical trial enrolled patients with newly diagnosed, advanced stage or bulky stage II, histologically confirmed DLBCL. Patients received six cycles of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone), two cycles of CHOP, then iodine-131 tositumomab radioimmunotherapy consolidation 30-60 d after completion of chemotherapy. The primary end-point was 2-year progression-free survival (PFS). Eighty-four eligible patients were enrolled, and 56 patients completed the entire course of protocol treatment. Of the 84 patients evaluable for treatment response, 72 [86%, 95% confidence interval (CI): 76-92%] achieved a partial response (n = 21) or a confirmed (n = 41) or unconfirmed (n = 10) complete response to therapy. With a median follow-up of 3.9 years, the 2-year PFS estimate is 69% and the 2-year overall survival estimate is 77%. Rituximab levels at time of radioimmunotherapy did not correlate with toxicity or outcome. Twenty percent of patients had double hit features (MYC+; BCL2+) by immunohistochemistry, and had inferior outcome. These current results suggest that the incorporation of novel agents earlier in therapy may ultimately have greater impact in DLBCL, as early progressions, deaths and declining performance status during CHOP chemotherapy limited the number of patients who ultimately could benefit from radioimmunotherapy consolidation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据