期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 161, 期 5, 页码 688-694出版社
WILEY
DOI: 10.1111/bjh.12332
关键词
Givinostat; histone-deacetylase inhibitor; hydroxycarbamide; polycythaemia vera; myeloproliferative neoplasm
类别
Givinostat, a histone-deacetylase inhibitor (HDACi), inhibits proliferation of cells bearing the JAK2 V617F mutation and has shown significant activity with good tolerability in patients with chronic myeloproliferative neoplasms (MPN). In this multicentre, open-label, phase II study, 44 patients with polycythaemia vera (PV), unresponsive to the maximum tolerated doses (MTD) of hydroxycarbamide (HC), were treated with Givinostat (50 or 100mg/d) in combination with MTD of HC. The European LeukaemiaNet response criteria were used to assess the primary endpoint after 12weeks of treatment. Complete or partial response was observed in 55% and 50% of patients receiving 50 or 100mg of Givinostat, respectively. Control of pruritus was observed in 64% and 67% of patients in the 50 and 100mg groups, respectively. The combination of Givinostat and HC was well tolerated: eight patients (18%) discontinued, four in each treatment arm; grade 3 adverse events were reported in one patient (4 center dot 5%) in each treatment arm. The combined use of Givinostat and HC was safe and clinically effective in HC-unresponsive PV patients.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据