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Nutlin-3 up-regulates the expression of Notch1 in both myeloid and lymphoid leukemic cells, as part of a negative feedback antiapoptotic mechanism
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Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development
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Activated Notch2 potentiates CD8 lineage maturation and promotes the selective development of B1B cells
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B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes
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BLOOD (2002)
Evidence that an IRES within the Notch2 coding region can direct expression of a nuclear form of the protein
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JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
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SCIENCE (2000)