期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 152, 期 6, 页码 766-770出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1365-2141.2010.08451.x
关键词
blood transfusion; sickle cell disease; iron overload
类别
资金
- Medical Research Council [G0000111] Funding Source: researchfish
- Medical Research Council [G0000111] Funding Source: Medline
- MRC [G0000111] Funding Source: UKRI
P>Transfusion of red blood cells is a major therapeutic option in sickle cell disease (SCD). There is strong evidence for its efficacy, particularly in primary and secondary stroke prevention in children, however, its use in other areas remains controversial. This study assessed the patterns of transfusion in the adult cohort attending King's College Hospital over a 10-year period, from 2000 to 2009. Total blood usage has increased significantly (P = 0 center dot 006) during this time, with 78% of the blood received by only 6% of the patients. The increase is explained by increased automated red cell exchange and increased usage for planned and acute transfusions for sickle-related complications.
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