期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 153, 期 4, 页码 499-503出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1365-2141.2011.08628.x
关键词
gain; miRNA; Affymetrix; aggressive lymphoma; bone marrow
类别
资金
- Oncosuisse [OCS-1939-8-2006]
- Swiss National Science Foundation [205321-112430, 205320-121886/1]
- Computational life science/Ticino in rete
- Fondazione per la Ricerca e la Cura sui Linfomi (Lugano)
- PHS [UO1 CA 114778]
- European Society for Medical Oncology (ESMO)
- Alto Adige Bolzano-AIL Onlus
- Swiss National Science Foundation (SNF) [205320-121886] Funding Source: Swiss National Science Foundation (SNF)
P>To characterize diffuse large B-cell lymphoma (DLBCL) with chromosome 7 gains, we combined clinical data with genomic, RNA and miRNA profiling. Gains were associated with age > 60 years, female gender, a trend for higher complete response rate, lower death rate, and better overall survival in patients treated with R-CHOP. Lesions were inversely associated with bone marrow involvement and number of extra-nodal sites. Differentially expressed transcripts were enriched of genes belonging to specific pathways and miRNAs targets. MIR96, MIR182, MIR589, MIR25 were shown significantly up-regulated in 7q+ DLBCL by real-time PCR.
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