期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 154, 期 4, 页码 482-485出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1365-2141.2011.08752.x
关键词
acute lymphoblastic leukaemia; childhood leukaemia; chemotherapy
类别
资金
- Medical Research Council [G0300130] Funding Source: researchfish
- MRC [G0300130] Funding Source: UKRI
- Medical Research Council [G0300130] Funding Source: Medline
Clofarabine is a second-generation purine nucleoside analogue, which has shown promising activity in relapsed and refractory paediatric acute lymphoblastic leukaemia (ALL). This report summarizes the early United Kingdom experience of clofarabine for the treatment of paediatric ALL in 23 patients, outside of the context of a clinical trial. Our results demonstrated that clofarabine-based chemotherapy regimes were effective and well-tolerated in this heavily pre-treated group, with an overall response rate of 67% when used in combination regimes. Responses were seen in both B and T cell disease and in patients with adverse cytogenetics.
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