期刊
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY
卷 39, 期 5, 页码 730-736出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/RCT.0000000000000263
关键词
carcinoma; renal cell; adult; multidetector computed tomography; diagnosis; differential; in situ hybridization; fluorescence
资金
- National Natural Science Foundation of China [21377052]
- Natural Science Foundation of Jiangsu Province [BK20131281]
- Fundamental Research Funds for the Central Universities [20620140664]
- Nanjing City Young Health Personnel Training Project [QRX11178]
Objective To investigate the dynamic contrast-enhanced computed tomography (CT) characteristics of renal cell carcinoma associated with Xp11.2 translocation and TFE gene fusion (Xp11.2 RCC) by comparison with clear cell renal cell carcinoma (CCRCC). Methods Dynamic contrast-enhanced CT images and clinical and pathological records of 20 adult patients with Xp11.2 RCC confirmed by TFE3 immunohistochemical and fluorescence in situ hybridization assay were retrospectively analyzed and compared with the findings of 21 contemporary CCRCCs. Results Renal cell carcinoma associated with Xp11.2 translocation and TFE gene fusions often occurred in young (30.6 8.6 years) patients with hematuria (9/20). They presented as well-defined (17/20) cystic-solid (17/20) mass with hemorrhage (8/20) and circular/rim calcifications (6/20). Dynamic contrast-enhanced CT showed heterogeneous moderate prolonged enhancement. A tumor-to-cortex attenuation ratio in corticomedullary phase less than 0.62 gave a sensitivity of 90.0% and a specificity of 92.9% in differentiating Xp11.2 RCC from CCRCC (area under the receiver operating characteristic curve = 0.957, P < 0.001). Conclusions Computed tomographic characteristics and dynamic contrast-enhanced patterns and index can differentiate Xp11.2 RCC from CCRCC.
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