期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 149, 期 3, 页码 410-413出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1365-2141.2010.08132.x
关键词
thrombosis; asparaginase; acute leukaemia; paediatric
类别
资金
- MRC [MC_U137686856, G0300130] Funding Source: UKRI
- Great Ormond Street Hospital Childrens Charity [V0903] Funding Source: researchfish
- Medical Research Council [MC_U137686856, G0300130] Funding Source: researchfish
- Medical Research Council [G0300130, MC_U137686856] Funding Source: Medline
P>We report the incidence and outcome of venous thrombosis (VT) in the UK acute lymphoblastic leukaemia (ALL) 2003 trial. VT occurred in 59/1824 (3 center dot 2%) patients recruited over 5 years with 90% occurring during a period of Asparagine depletion. Pegylated Escherichia Coli Asparaginase (Peg-ASP) 1000 units/m2 was used throughout. Thirty-four children received further Peg-ASP, most with concurrent heparin prophylaxis. There were no episodes of bleeding or recurrent thrombosis. Optimal Asparagine depletion is central to success of modern regimes for treatment of ALL. This report confirms a significant risk of thrombosis with such therapy, but demonstrates that re-exposure to Asparaginase is feasible and safe.
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