期刊
BREAST CANCER RESEARCH
卷 12, 期 6, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/bcr2797
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资金
- NHMRC [251533, 209057, 504711]
- National Breast Cancer Foundation
- Cancer Australia [628333]
- European Community [223175 (HEALTH-F2-2009-223175)]
- Red Tematica de Investigacion Cooperativa en Cancer
- Asociacion Espanola Contra Cancer
- Fondo de Investigacion Santiario [PI081583, PI081120]
- Cancer Research UK
- Breakthrough Breast Cancer
- NHS
- National Cancer Institute, Department of Health and Human Services, USA
- National Institutes of Health, National Cancer Institute [CA-58860, CA-92044]
- Lon V Smith Foundation [LVS-39420]
- United States National Cancer Institute, National Institutes of Health (NIH) [RFA-CA-06-503]
- Cancer Care Ontario [U01 CA69467]
- Northern California Cancer Center [U01 CA69417]
- University of Melbourne [U01 CA69638]
- National Health and Medical Research Council of Australia
- New South Wales Cancer Council
- Victorian Health Promotion Foundation (Australia)
- Victorian Breast Cancer Research Consortium
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Kuopio University Hospital
- Vaasa Central Hospital
- Academy of Finland
- Finnish Cancer Foundation
- Yorkshire Cancer Research
- Breast Cancer Campaign
- Federal Ministry of Education and Research (BMBF) Germany [01KW9975/5, 01KW9976/8, 01KW9977/0, 01KW0114]
- Robert Bosch Foundation of Medical Research, Stuttgart
- Deutsches Krebsforschungszentrum (DKFZ) Heidelberg
- Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum
- Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH
- Johanniter Krankenhaus, Bonn, Germany
- European Union [LSHC-CT-2003-503297]
- Stichting tegen Kanker [232-2008]
- Deutsche Krebshilfe e. V. [70492, 70-2892-BR I]
- state of Baden-Wurttemberg through the Medical Faculty of the University of Ulm [P. 685]
- Queensland Cancer Fund
- Cancer Council of New South Wales
- Cancer Council of Victoria
- Cancer Council of Tasmania
- Cancer Council of South Australia
- Cancer Foundation of Western Australia
- U.S. Army Medical Research and Materiel Command [DAMD17-01-1-0729]
- Cancer Council Tasmania
- Chief Physician Johan Boserup and Lise Boserup Fund
- Danish Medical Research Council
- Copenhagen University Hospital
- Herlev Hospital
- NIH [CA122340, CA116201]
- Hamburg Cancer Society
- German Cancer Research Center
- University Hospital of Erlangen
- Dr. Mildred Scheel Foundation of the Deutsche Krebshilfe
- Agency for Science, Technology and Research of Singapore (A*STAR)
- NIH
- Susan G. Komen Breast Cancer Foundation
- Cancer Research UK [11022, 10118, 11021] Funding Source: researchfish
- The Francis Crick Institute [10119, 10124] Funding Source: researchfish
- NATIONAL CANCER INSTITUTE [U01CA069467, ZIACP010126, U01CA069638, U01CA069417, R01CA122340, P50CA116201, U01CA058860, R01CA058860] Funding Source: NIH RePORTER
Introduction: Several common breast cancer genetic susceptibility variants have recently been identified. We aimed to determine how these variants combine with a subset of other known risk factors to influence breast cancer risk in white women of European ancestry using case-control studies participating in the Breast Cancer Association Consortium. Methods: We evaluated two-way interactions between each of age at menarche, ever having had a live birth, number of live births, age at first birth and body mass index (BMI) and each of 12 single nucleotide polymorphisms (SNPs) (10q26-rs2981582 (FGFR2), 8q24-rs13281615, 11p15-rs3817198 (LSP1), 5q11-rs889312 (MAP3K1), 16q12-rs3803662 (TOX3), 2q35-rs13387042, 5p12-rs10941679 (MRPS30), 17q23-rs6504950 (COX11), 3p24-rs4973768 (SLC4A7), CASP8-rs17468277, TGFB1-rs1982073 and ESR1-rs3020314). Interactions were tested for by fitting logistic regression models including per-allele and linear trend main effects for SNPs and risk factors, respectively, and single-parameter interaction terms for linear departure from independent multiplicative effects. Results: These analyses were applied to data for up to 26,349 invasive breast cancer cases and up to 32,208 controls from 21 case-control studies. No statistical evidence of interaction was observed beyond that expected by chance. Analyses were repeated using data from 11 population-based studies, and results were very similar. Conclusions: The relative risks for breast cancer associated with the common susceptibility variants identified to date do not appear to vary across women with different reproductive histories or body mass index (BMI). The assumption of multiplicative combined effects for these established genetic and other risk factors in risk prediction models appears justified.
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